{"product_id":"avsar-plus-10-160-12-5mg","title":"Avsar Plus 10\/160\/12.5mg","description":"\u003cp\u003eMedicine Name: Avsar Plus Tablets 160\/10\/12.5mg\u003c\/p\u003e\n\u003cp\u003e💊 Avsar Plus Tablets – Specification\u003cbr\u003e________________________________________\u003cbr\u003e📄 Requires Prescription:\u003cbr\u003e✅ Yes\u003cbr\u003e________________________________________\u003cbr\u003e🧪 Generics (Active Ingredients):\u003cbr\u003e•    Valsartan\u003cbr\u003e•    Amlodipine\u003cbr\u003e•    Hydrochlorothiazide\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e🎯 Used For:\u003cbr\u003eManagement of Essential Hypertension in adults\u003cbr\u003e________________________________________\u003cbr\u003e⚙️ How It Works:\u003cbr\u003e•    Valsartan (ARB): Blocks angiotensin II, reducing vasoconstriction and aldosterone-related sodium\/water retention.\u003cbr\u003e•    Amlodipine (Calcium Channel Blocker): Inhibits calcium influx into vascular smooth muscle and myocardium, leading to vasodilation.\u003cbr\u003e•    Hydrochlorothiazide (Thiazide Diuretic): Inhibits Na⁺\/Cl⁻ reabsorption in the kidneys, promoting diuresis and lowering blood volume.\u003cbr\u003eCombined, these agents reduce blood pressure via complementary mechanisms.\u003cbr\u003e________________________________________\u003cbr\u003e📋 Usage and Safety\u003cbr\u003e________________________________________\u003cbr\u003e💊 Dosage:\u003cbr\u003eAs prescribed by a physician. Based on clinical evaluation of blood pressure, kidney function, and patient response.\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Side Effects:\u003cbr\u003eHematologic:\u003cbr\u003e•    Agranulocytosis, aplastic anemia, leukopenia, neutropenia, thrombocytopenia\u003cbr\u003eMetabolic:\u003cbr\u003e•    Hyperuricemia, hyperglycemia, hypokalemia, hypomagnesemia, hypercalcemia, hypochloremic alkalosis\u003cbr\u003eNeurological:\u003cbr\u003e•    Headache, visual disturbances, hypertonia\u003cbr\u003eCardiac:\u003cbr\u003e•    Bradycardia, ventricular tachycardia, atrial fibrillation (arrhythmias)\u003cbr\u003eOthers:\u003cbr\u003e•    Anorexia, bone marrow suppression\u003cbr\u003e________________________________________\u003cbr\u003e🔄 Drug Interactions:\u003cbr\u003e•    Amlodipine:\u003cbr\u003eCYP3A4 inhibitors (e.g. ketoconazole, erythromycin), CYP3A4 inducers (rifampicin, phenytoin), grapefruit juice, simvastatin, sildenafil, dantrolene, immunosuppressants\u003cbr\u003e•    Valsartan:\u003cbr\u003ePotassium-sparing diuretics, potassium supplements, NSAIDs (including COX-2 inhibitors), lithium, rifampicin, cyclosporine, ritonavir\u003cbr\u003e•    Hydrochlorothiazide:\u003cbr\u003eLithium, metformin, antidepressants, antipsychotics, antiepileptics (e.g., carbamazepine), cholestyramine, digitalis glycosides, alcohol, barbiturates, cytotoxic agents\u003cbr\u003e________________________________________\u003cbr\u003e📌 Indication:\u003cbr\u003eFor the treatment of essential hypertension where combination therapy is appropriate.\u003cbr\u003e________________________________________\u003cbr\u003e🚫 When Not to Use:\u003cbr\u003e•    Known hypersensitivity to valsartan, amlodipine, hydrochlorothiazide, or related substances (sulphonamides\/dihydropyridines)\u003cbr\u003e•    Pregnancy (2nd and 3rd trimester)\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, or cholestasis\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Precautions and Warnings\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Precaution:\u003cbr\u003eUse with caution in patients with:\u003cbr\u003e•    Unilateral\/bilateral renal artery stenosis\u003cbr\u003e•    Single kidney (risk of increased blood urea and serum creatinine)\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Warnings:\u003cbr\u003e1.    Pregnancy Risk:\u003cbr\u003eDrugs affecting the renin-angiotensin system during 2nd\/3rd trimesters may cause fetal injury or death (renal dysfunction, oligohydramnios, skeletal issues).\u003cbr\u003e2.    Volume\/Salt Depletion:\u003cbr\u003eSymptomatic hypotension may occur in patients with reduced intravascular volume (e.g. high-dose diuretic use).\u003cbr\u003e3.    Renal Impairment:\u003cbr\u003eCan lead to acute renal failure, especially in patients with compromised renal function or under diuretic therapy.\u003cbr\u003e________________________________________\u003cbr\u003e🧾 Additional Information\u003cbr\u003e________________________________________\u003cbr\u003e🤰 Pregnancy Category:\u003cbr\u003eAvoid during pregnancy. Always consult your physician before use.\u003cbr\u003e________________________________________\u003cbr\u003e📦 Storage Required:\u003cbr\u003e✅ Yes – Store at room temperature, protected from direct light and heat.\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53257151742283,"sku":null,"price":530.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_6748_8a2fb6a5-a2ba-4da0-a05e-a7f6406c186e.jpg?v=1756270814","url":"https:\/\/wellnesspharmacy.pk\/products\/avsar-plus-10-160-12-5mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}