{"product_id":"avsar-plus-10-160-25mg","title":"Avsar Plus 10\/160\/25mg","description":"\u003cp\u003eMedicine Name: Avsar Plus Tablet 160\/10\/25mg\u003cbr\u003e💊 Avsar Plus Tablets – Product Specification\u003cbr\u003e________________________________________\u003cbr\u003e✅ Requires Prescription\u003cbr\u003eYes\u003cbr\u003e________________________________________\u003cbr\u003e🧪 Generics\u003cbr\u003e•    Valsartan (ARB – Angiotensin II Receptor Blocker)\u003cbr\u003e•    Amlodipine (Calcium Channel Blocker)\u003cbr\u003e•    Hydrochlorothiazide (Thiazide Diuretic)\u003cbr\u003e________________________________________\u003cbr\u003e🩺 Used For\u003cbr\u003eTreatment of Essential Hypertension in adults\u003cbr\u003e________________________________________\u003cbr\u003e⚙️ How It Works\u003cbr\u003e•    Valsartan: Blocks angiotensin II effects, reducing vasoconstriction and aldosterone release, leading to lower blood pressure.\u003cbr\u003e•    Amlodipine: Relaxes vascular smooth muscle by inhibiting calcium influx, resulting in vasodilation and reduced blood pressure.\u003cbr\u003e•    Hydrochlorothiazide: Inhibits Na⁺\/Cl⁻ symporter in kidneys, promoting sodium and water excretion, reducing blood volume and pressure.\u003cbr\u003e________________________________________\u003cbr\u003e📋 Usage and Safety\u003cbr\u003e💊 Dosage\u003cbr\u003eCombination: Valsartan + Amlodipine + Hydrochlorothiazide\u003cbr\u003eExact strength and frequency to be determined by a healthcare provider.\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Side Effects\u003cbr\u003e•    Hematologic: Agranulocytosis, bone marrow suppression, aplastic anemia, leukopenia, thrombocytopenia\u003cbr\u003e•    Metabolic: Hypokalemia, hypomagnesemia, hypercalcemia, hyperglycemia, hyperuricemia, hyperlipidemia\u003cbr\u003e•    Neurological\/Cardiac: Headache, hypertonia, arrhythmias (bradycardia, tachycardia, AFib), visual disturbances\u003cbr\u003e•    GI\/Other: Anorexia, hemolytic anemia, electrolyte imbalances, hypochloremic alkalosis\u003cbr\u003e________________________________________\u003cbr\u003e🔄 Drug Interactions\u003cbr\u003e•    Amlodipine:\u003cbr\u003eo    CYP3A4 inhibitors (e.g. ketoconazole, ritonavir)\u003cbr\u003eo    CYP3A4 inducers (e.g. carbamazepine, rifampicin)\u003cbr\u003eo    Simvastatin, Sildenafil, grapefruit juice, immunosuppressants\u003cbr\u003e•    Valsartan:\u003cbr\u003eo    Potassium-sparing diuretics, potassium supplements\u003cbr\u003eo    NSAIDs (including COX-2 inhibitors), lithium, rifampicin, cyclosporine, ritonavir\u003cbr\u003e•    Hydrochlorothiazide:\u003cbr\u003eo    Antidiabetics (e.g. metformin), antidepressants\u003cbr\u003eo    Cholestyramine, digitalis glycosides, cytotoxic agents\u003cbr\u003eo    Alcohol, barbiturates, methyldopa, lithium\u003cbr\u003e________________________________________\u003cbr\u003e🚫 When Not to Use\u003cbr\u003e•    Known hypersensitivity to valsartan, amlodipine, hydrochlorothiazide, or sulfonamide\/dihydropyridine derivatives\u003cbr\u003e•    Pregnancy (2nd \u0026amp; 3rd trimesters)\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, or cholestasis\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e⚠️ Precautions \u0026amp; Warnings\u003cbr\u003e⚠️ Precaution\u003cbr\u003eUse with caution in renal artery stenosis or solitary kidney due to risk of elevated serum creatinine and blood urea nitrogen.\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Warnings\u003cbr\u003e1.    Fetal Risk:\u003cbr\u003eUse of renin-angiotensin inhibitors during pregnancy can lead to fetal injury\/death (oligohydramnios, renal dysfunction, skeletal deformities).\u003cbr\u003e2.    Hypotension Risk:\u003cbr\u003ePatients with volume\/salt depletion (e.g., due to diuretics) may experience symptomatic hypotension.\u003cbr\u003e3.    Renal Function:\u003cbr\u003eUse may result in acute renal failure, particularly in those with compromised kidney function or on concurrent nephrotoxic agents.\u003cbr\u003e________________________________________\u003cbr\u003e📎 Additional Information\u003cbr\u003e•    Pregnancy Category:\u003cbr\u003e⚠️ Not safe during pregnancy – consult your physician\u003cbr\u003e•    Storage:\u003cbr\u003e✅ Store at room temperature, protected from direct light and heat\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53257251750219,"sku":null,"price":540.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_6748_4fa2deab-76a0-491c-a5b4-455c8b775dbe.jpg?v=1756271199","url":"https:\/\/wellnesspharmacy.pk\/products\/avsar-plus-10-160-25mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}