{"product_id":"avsar-plus-5-160-12-5mg","title":"Avsar Plus 5\/160\/12.5mg","description":"\u003cp\u003eMedicine Name: Avsar Plus Tablets 160mg\/5mg\/12.5mg\u003c\/p\u003e\n\u003cp\u003e💊 Avsar Plus Tablets – Product Specification\u003cbr\u003e________________________________________\u003cbr\u003e📌 Requires Prescription:\u003cbr\u003e✅ Yes\u003cbr\u003e________________________________________\u003cbr\u003e🧬 Generics:\u003cbr\u003eValsartan + Amlodipine + Hydrochlorothiazide\u003cbr\u003e________________________________________\u003cbr\u003e🎯 Used For:\u003cbr\u003eTreatment of essential hypertension (high blood pressure) in adults\u003cbr\u003e________________________________________\u003cbr\u003e⚙️ How It Works:\u003cbr\u003e•    Valsartan: An angiotensin II receptor blocker (ARB) that reduces vasoconstriction and aldosterone secretion, lowering blood pressure.\u003cbr\u003e•    Amlodipine: A calcium channel blocker that inhibits calcium ion influx into vascular smooth muscle and cardiac muscle, causing vasodilation.\u003cbr\u003e•    Hydrochlorothiazide (HCT): A thiazide diuretic that promotes sodium and chloride excretion, decreasing plasma volume and blood pressure.\u003cbr\u003eThese agents act synergistically to control blood pressure more effectively than individual therapy.\u003cbr\u003e________________________________________\u003cbr\u003e📋 Usage \u0026amp; Safety\u003cbr\u003e________________________________________\u003cbr\u003e💊 Dosage:\u003cbr\u003eValsartan + Amlodipine + Hydrochlorothiazide\u003cbr\u003e→ Dosage as directed by a physician, based on patient condition and response.\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e⚠️ Side Effects:\u003cbr\u003eBlood \u0026amp; Metabolic:\u003cbr\u003e•    Agranulocytosis, bone marrow failure, aplastic anemia\u003cbr\u003e•    Hemolytic anemia, leukopenia, neutropenia, thrombocytopenia\u003cbr\u003e•    Hypokalemia, hypomagnesemia, hyperuricemia, hyperglycemia, hypercalcemia\u003cbr\u003eNeurological:\u003cbr\u003e•    Headache, hypertonia, visual disturbances\u003cbr\u003eCardiovascular:\u003cbr\u003e•    Arrhythmias (bradycardia, ventricular tachycardia, atrial fibrillation)\u003cbr\u003e________________________________________\u003cbr\u003e🔄 Drug Interactions:\u003cbr\u003eAmlodipine:\u003cbr\u003e•    CYP3A4 inhibitors: ketoconazole, itraconazole, erythromycin, clarithromycin\u003cbr\u003e•    CYP3A4 inducers: carbamazepine, phenytoin, rifampicin\u003cbr\u003e•    Sildenafil, simvastatin, grapefruit juice\u003cbr\u003e•    Immunosuppressants, dantrolene\u003cbr\u003eValsartan:\u003cbr\u003e•    Potassium-sparing diuretics, potassium supplements, NSAIDs, lithium, rifampicin\u003cbr\u003eHydrochlorothiazide:\u003cbr\u003e•    Lithium, metformin, cholestyramine, colestipol\u003cbr\u003e•    Beta-blockers, digitalis glycosides, cytotoxic agents, methyldopa\u003cbr\u003e•    Alcohol, barbiturates, narcotics\u003cbr\u003e________________________________________\u003cbr\u003e🩺 Indication:\u003cbr\u003eUsed for management of essential hypertension in adults when combination therapy is appropriate.\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e🚫 When Not to Use:\u003cbr\u003e•    Hypersensitivity to any of the active ingredients or related compounds (sulphonamides, dihydropyridines)\u003cbr\u003e•    Pregnancy (especially second and third trimesters)\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, or cholestasis\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Precautions \u0026amp; Warnings\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Precaution:\u003cbr\u003eUse with caution in patients with renal artery stenosis, especially those with a single functioning kidney — risk of raised creatinine\/urea.\u003cbr\u003e________________________________________\u003cbr\u003e🚨 Warnings:\u003cbr\u003e1.    Pregnancy Risk (Black Box Warning):\u003cbr\u003eUse of renin-angiotensin inhibitors during 2nd\/3rd trimester can harm the fetus (renal failure, lung hypoplasia, skeletal deformities).\u003cbr\u003e2.    Volume Depletion:\u003cbr\u003eIn salt- or volume-depleted patients, symptomatic hypotension may occur — correct condition before initiating therapy or monitor closely.\u003cbr\u003e3.    Renal Function Impairment:\u003cbr\u003eCan cause or worsen renal dysfunction including acute renal failure, especially with diuretics or in patients with underlying renal disease.\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e🧾 Additional Information\u003cbr\u003e________________________________________\u003cbr\u003e🤰 Pregnancy Category:\u003cbr\u003eConsult your physician. Contraindicated in 2nd and 3rd trimester.\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e🧊 Storage Required:\u003cbr\u003e✅ Yes\u003cbr\u003eStore at room temperature, away from direct light and heat.\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53257015001419,"sku":null,"price":490.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_6748_b51d5872-101d-4083-ae0a-f6ef7599cede.jpg?v=1756270286","url":"https:\/\/wellnesspharmacy.pk\/products\/avsar-plus-5-160-12-5mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}