{"product_id":"avsar-plus-5-160-25mg","title":"Avsar Plus 5\/160\/25mg","description":"\u003cp\u003eMedicine Name: Avsar Plus Tablets 160\/5\/25mg\u003cbr\u003e💊 Avsar Plus Tablets – Product Specification\u003cbr\u003e________________________________________\u003cbr\u003e✅ Requires Prescription\u003cbr\u003eYes\u003cbr\u003e________________________________________\u003cbr\u003e🧪 Generic Components\u003cbr\u003e•    Valsartan (ARB)\u003cbr\u003e•    Amlodipine (Calcium Channel Blocker)\u003cbr\u003e•    Hydrochlorothiazide (Thiazide Diuretic)\u003cbr\u003e________________________________________\u003cbr\u003e🩺 Used For\u003cbr\u003eTreatment of Essential Hypertension in adults\u003cbr\u003e________________________________________\u003cbr\u003e⚙️ How It Works\u003cbr\u003e•    Valsartan: Blocks angiotensin II, preventing vasoconstriction and aldosterone release, thereby lowering blood pressure.\u003cbr\u003e•    Amlodipine: Inhibits calcium entry into vascular smooth muscle, causing vasodilation and lowering blood pressure.\u003cbr\u003e•    Hydrochlorothiazide: Inhibits Na⁺\/Cl⁻ reabsorption in kidneys, increasing diuresis, reducing blood volume and blood pressure.\u003cbr\u003eThese agents work synergistically to provide enhanced blood pressure control.\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e📋 Usage and Safety\u003cbr\u003e💊 Dosage\u003cbr\u003eBased on individual patient needs and physician evaluation. Follow the doctor’s prescription strictly.\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e⚠️ Side Effects\u003cbr\u003e•    Hematological:\u003cbr\u003eAgranulocytosis, bone marrow suppression, hemolytic anemia, leukopenia, neutropenia, thrombocytopenia, aplastic anemia\u003cbr\u003e•    Metabolic\/Electrolyte:\u003cbr\u003eHypercalcemia, hyperglycemia, hyperlipidemia, hyperuricemia, hypokalemia, hypomagnesemia, hypochloremic alkalosis\u003cbr\u003e•    Neurological \u0026amp; Cardiac:\u003cbr\u003eHeadache, visual disturbances, hypertonia, arrhythmias (e.g., bradycardia, ventricular tachycardia, atrial fibrillation)\u003cbr\u003e•    Others:\u003cbr\u003eAnorexia\u003cbr\u003e________________________________________\u003cbr\u003e🔄 Drug Interactions\u003cbr\u003e•    Amlodipine:\u003cbr\u003eo    CYP3A4 inhibitors (e.g. ketoconazole, erythromycin)\u003cbr\u003eo    CYP3A4 inducers (e.g. rifampicin, phenytoin)\u003cbr\u003eo    Grapefruit juice, simvastatin, sildenafil\u003cbr\u003eo    Immunosuppressants, dantrolene\u003cbr\u003e•    Valsartan:\u003cbr\u003eo    Potassium-sparing diuretics (e.g. spironolactone)\u003cbr\u003eo    Heparin, lithium, NSAIDs\u003cbr\u003eo    Rifampicin, cyclosporin, ritonavir\u003cbr\u003e•    Hydrochlorothiazide:\u003cbr\u003eo    Antidiabetics (e.g. metformin), antidepressants, antiepileptics\u003cbr\u003eo    Cholestyramine, lithium, digitalis glycosides\u003cbr\u003eo    Alcohol, barbiturates, cytotoxic agents\u003cbr\u003eo    Methyldopa, iodine contrast, tubocurarine\u003cbr\u003e________________________________________\u003cbr\u003e🚫 Contraindications (When Not to Use)\u003cbr\u003e•    Hypersensitivity to any active ingredient or related drug class (e.g., sulphonamides, dihydropyridines)\u003cbr\u003e•    Pregnancy (especially 2nd and 3rd trimesters)\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, or cholestasis\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e⚠️ Precautions \u0026amp; Warnings\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Precaution\u003cbr\u003e•    Use caution in patients with renal artery stenosis (unilateral\/bilateral) or single kidney—may cause increased serum creatinine and urea.\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Warnings\u003cbr\u003e1.    Pregnancy Risk:\u003cbr\u003eDrugs acting on the renin-angiotensin system can cause fetal injury or death in 2nd\/3rd trimesters (e.g., renal dysfunction, skeletal deformities).\u003cbr\u003e2.    Volume\/Salt Depletion:\u003cbr\u003eSymptomatic hypotension can occur in patients on high-dose diuretics. Stabilize before starting treatment.\u003cbr\u003e3.    Renal Risk:\u003cbr\u003eRisk of acute renal failure due to the combined effects of valsartan and diuretics.\u003cbr\u003e________________________________________\u003cbr\u003e📎 Additional Information\u003cbr\u003e•    Pregnancy Category:\u003cbr\u003eNot recommended during pregnancy—consult your physician before use.\u003cbr\u003e•    Storage:\u003cbr\u003e✅ Yes – Store at room temperature, protected from light and heat.\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53257345696075,"sku":null,"price":502.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_6748_a7ef59b3-f14d-429b-b754-5f945a608bae.jpg?v=1756271374","url":"https:\/\/wellnesspharmacy.pk\/products\/avsar-plus-5-160-25mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}