{"product_id":"co-depricap-capsules-3-25mg","title":"Co-depricap Capsules 3\/25mg","description":"\u003cp\u003e1. Basic Information\u003cbr\u003e Prescription Required: ✅ Yes\u003cbr\u003e Generic Components:\u003cbr\u003eo Olanzapine\u003cbr\u003eo Fluoxetine\u003cbr\u003e Used For:\u003cbr\u003eo Depressive episodes in Bipolar I Disorder\u003cbr\u003eo Treatment-resistant Major Depressive Disorder (MDD)\u003cbr\u003e2. Mechanism of Action\u003cbr\u003e Fluoxetine:\u003cbr\u003eA selective serotonin reuptake inhibitor (SSRI). Inhibits CNS neuronal reuptake of\u003cbr\u003eserotonin (5-HT) with minimal effect on norepinephrine or dopamine. Does not bind to\u003cbr\u003ealpha-adrenergic, histaminergic, or cholinergic receptors.\u003cbr\u003e Olanzapine:\u003cbr\u003eAtypical antipsychotic. Potent antagonist of dopamine (D1–D3), serotonin (5-HT2A, 5-\u003cbr\u003eHT2C), histamine H1, and alpha1-adrenergic receptors. Moderate antagonism at\u003cbr\u003emuscarinic M1–M5 and 5-HT3 receptors; also binds GABA-A, benzodiazepine, and βadrenergic receptors.\u003cbr\u003e3. Dosage\u003cbr\u003e Contains fixed-dose combination of Olanzapine + Fluoxetine\u003cbr\u003e Dosage varies based on clinical condition and patient tolerance—must be prescribed by\u003cbr\u003ea physician\u003cbr\u003e4. Side Effects\u003cbr\u003e Common to Severe Effects Include:\u003cbr\u003eo Neurological: Chills, neck rigidity, QT prolongation\u003cbr\u003eo Gastrointestinal: Diarrhea, nausea, vomiting, peptic ulcer, GI bleeding, intestinal\u003cbr\u003eobstruction\u003cbr\u003eo Hepatic \u0026amp; Renal: Liver fatty deposit, bilirubinemia, pancreatitis, elevated\u003cbr\u003ecreatinine\u003cbr\u003eo Hematologic: Anemia, leukopenia, thrombocytopenia, purpura\u003cbr\u003eo Musculoskeletal: Osteoporosis\u003cbr\u003eo Other: Photosensitivity, weight loss, ecchymosis, generalized edema, gout\u003cbr\u003e5. Drug Interactions\u003cbr\u003eAvoid or use caution with:\u003cbr\u003e MAOIs (contraindicated)\u003cbr\u003e CNS-active agents (e.g., benzodiazepines, antipsychotics, SSRIs)\u003cbr\u003e Serotonergic agents, triptans, tryptophan\u003cbr\u003e Anticoagulants\/NSAIDs (e.g., aspirin, warfarin)\u003cbr\u003e CYP1A2 inducers\/inhibitors\u003cbr\u003e Tricyclic antidepressants, antiepileptics, antihypertensives, lithium, valproate,\u003cbr\u003etheophylline\u003cbr\u003e6. Indications\u003cbr\u003e Depressive Episodes in Bipolar I Disorder (Adults)\u003cbr\u003e Treatment-Resistant Depression (Adults): For MDD that has not responded to two\u003cbr\u003eseparate antidepressants of adequate dose and duration\u003cbr\u003e7. Contraindications (When NOT to Use)\u003cbr\u003e Concurrent use of MAOIs, Pimozide, or Thioridazine\u003cbr\u003e Known hypersensitivity to Olanzapine, Fluoxetine, or any tablet component\u003cbr\u003e8. Precautions\u003cbr\u003e Patients on antidepressants should be closely monitored for:\u003cbr\u003eo Clinical worsening\u003cbr\u003eo Emergent suicidality\u003cbr\u003eo Behavioral changes (especially during first few months or dose changes)\u003cbr\u003e9. Warnings\u003cbr\u003eWarning 1:\u003cbr\u003eIn cases of worsening depression or new suicidality, consider modifying or discontinuing\u003cbr\u003etherapy.\u003cbr\u003eWarning 2:\u003cbr\u003ePatients with MDD may experience worsening mood or emergence of suicidal thoughts—this\u003cbr\u003erisk exists regardless of medication use.\u003cbr\u003eWarning 3:\u003cbr\u003eAlthough the suicidality risk with long-term use is unclear, maintenance therapy has shown\u003cbr\u003ebenefit in delaying recurrence in adults.\u003cbr\u003e10. Additional Information\u003cbr\u003e Pregnancy Category: Consult your physician\u003cbr\u003e Storage Required: ✅ Yes\u003cbr\u003eo Store at room temperature, away from direct light and heat\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53279712608587,"sku":null,"price":140.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_7211.jpg?v=1756522163","url":"https:\/\/wellnesspharmacy.pk\/products\/co-depricap-capsules-3-25mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}