{"product_id":"co-diovan-tablets-80mg-12-5mg","title":"Co-Diovan Tablets 80mg\/12.5mg","description":"\u003cp\u003eMedicine Name: Co-Diovan Tablets 80mg\/12.5mg\u003c\/p\u003e\n\u003cp\u003e📄 Co-Diovan Tablets – Product Specification\u003cbr\u003e________________________________________\u003cbr\u003eRequires Prescription:\u003cbr\u003e✅ Yes\u003cbr\u003e________________________________________\u003cbr\u003eGenerics:\u003cbr\u003eValsartan + Hydrochlorothiazide\u003cbr\u003e________________________________________\u003cbr\u003eUsed For:\u003cbr\u003e•    Hypertension (to lower blood pressure)\u003cbr\u003e________________________________________\u003cbr\u003eHow It Works:\u003cbr\u003eValsartan:\u003cbr\u003e•    Blocks angiotensin II from binding to the AT1 receptor in tissues like vascular smooth muscle and adrenal glands.\u003cbr\u003e•    This prevents vasoconstriction and aldosterone secretion, reducing blood pressure.\u003cbr\u003e•    Its effect is independent of angiotensin II synthesis pathway.\u003cbr\u003eHydrochlorothiazide:\u003cbr\u003e•    A thiazide diuretic that increases sodium and chloride excretion, leading to reduced plasma volume.\u003cbr\u003e•    This results in increased renin activity, aldosterone secretion, potassium loss, and reduced serum potassium.\u003cbr\u003e•    The exact mechanism of its antihypertensive effect is not fully known.\u003cbr\u003e________________________________________\u003cbr\u003eUsage and Safety\u003cbr\u003eDosage:\u003cbr\u003e•    Valsartan + Hydrochlorothiazide (Exact dose based on physician’s prescription)\u003cbr\u003e________________________________________\u003cbr\u003eSide Effects:\u003cbr\u003eUncommon:\u003cbr\u003e•    Dehydration\u003cbr\u003e•    Paresthesia\u003cbr\u003e•    Blurred vision\u003cbr\u003e•    Tinnitus\u003cbr\u003e•    Hypotension\u003cbr\u003e•    Cough\u003cbr\u003e•    Myalgia\u003cbr\u003e•    Fatigue\u003cbr\u003eVery Rare:\u003cbr\u003e•    Dizziness\u003cbr\u003e•    Diarrhea\u003cbr\u003e•    Arthralgia\u003cbr\u003eFrequency Not Known:\u003cbr\u003e•    Syncope\u003cbr\u003e•    Non-cardiogenic pulmonary edema\u003cbr\u003e•    Impaired renal function\u003cbr\u003e•    Elevated serum uric acid, bilirubin, creatinine\u003cbr\u003e•    Hypokalemia\u003cbr\u003e•    Hyponatremia\u003cbr\u003e•    Elevated blood urea nitrogen (BUN)\u003cbr\u003e•    Neutropenia\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003eDrug Interactions:\u003cbr\u003eUse caution with:\u003cbr\u003e•    Lithium\u003cbr\u003e•    Rifampin, ciclosporin, ritonavir\u003cbr\u003e•    Antidepressants, antipsychotics, antiepileptics\u003cbr\u003e•    Allopurinol, noradrenaline, methyldopa\u003cbr\u003e•    Atropine, biperiden\u003cbr\u003e•    Cholestyramine, colestipol\u003cbr\u003e•    Probenecid, sulfinpyrazone\u003cbr\u003e•    Potassium, kaliuretic diuretics\u003cbr\u003e•    Tetracyclines, carbamazepine\u003cbr\u003e•    Alcohol, anesthetics, sedatives\u003cbr\u003e•    Penicillin G, salicylates, antiarrhythmics\u003cbr\u003e•    Cyclosporine\u003cbr\u003e________________________________________\u003cbr\u003eIndication:\u003cbr\u003e•    Management of essential hypertension where combination therapy is appropriate\u003cbr\u003e________________________________________\u003cbr\u003eWhen Not to Use:\u003cbr\u003eContraindicated in:\u003cbr\u003e•    Hypersensitivity to Valsartan, Hydrochlorothiazide, or sulfonamide-derived drugs\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, cholestasis\u003cbr\u003e________________________________________\u003cbr\u003ePrecautions:\u003cbr\u003e•    Use caution in volume- or salt-depleted patients (e.g., on high-dose diuretics)\u003cbr\u003e•    Monitor blood pressure closely; symptomatic hypotension may occur\u003cbr\u003e•    May need to correct volume status before starting therapy\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eWarnings:\u003cbr\u003e🔴 Warning 1:\u003cbr\u003ePhotosensitivity may occur with thiazides. If present, discontinue and consider sun protection if re-administered.\u003cbr\u003e🔴 Warning 2:\u003cbr\u003eAllergic reactions may occur with hydrochlorothiazide in patients with history of asthma or allergy.\u003cbr\u003e🔴 Warning 3:\u003cbr\u003eHydrochlorothiazide can alter glucose tolerance and elevate cholesterol\/triglycerides.\u003cbr\u003e________________________________________\u003cbr\u003ePregnancy Category:\u003cbr\u003e⚠️ Always consult a physician before use, especially during pregnancy.\u003cbr\u003e________________________________________\u003cbr\u003eStorage:\u003cbr\u003e✅ Yes – Store at room temperature, away from light and heat\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53312811958603,"sku":null,"price":2340.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/07317.webp?v=1756978076","url":"https:\/\/wellnesspharmacy.pk\/products\/co-diovan-tablets-80mg-12-5mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}