{"product_id":"dioplus-tablets-10-160mg","title":"Dioplus Tablets 10\/160mg","description":"\u003cp\u003eMedicine Name: Dioplus Tablets 10\/160mg\u003c\/p\u003e\n\u003cp\u003e📄 Dioplus Tablets – Product Specification\u003cbr\u003e________________________________________\u003cbr\u003e📌 Requires Prescription:\u003cbr\u003eYes\u003cbr\u003e________________________________________\u003cbr\u003e🧪 Generics:\u003cbr\u003eAmlodipine Besilate + Valsartan\u003cbr\u003e________________________________________\u003cbr\u003e💉 Used For:\u003cbr\u003eTreatment of Hypertension (high blood pressure)\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e⚙️ How It Works:\u003cbr\u003e•    Amlodipine is a calcium channel blocker that relaxes vascular smooth muscle, reducing peripheral resistance.\u003cbr\u003e•    Valsartan is an angiotensin II receptor blocker (ARB) that prevents vasoconstriction and aldosterone secretion.\u003cbr\u003e•    Their complementary mechanisms produce an additive antihypertensive effect, offering improved blood pressure control compared to either drug alone.\u003cbr\u003e________________________________________\u003cbr\u003e💊 Dosage:\u003cbr\u003eAmlodipine Besilate + Valsartan\u003cbr\u003e(Dosage must be prescribed by a qualified healthcare professional based on patient-specific factors.)\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Side Effects:\u003cbr\u003e•    Common:\u003cbr\u003eo    Nasopharyngitis, influenza\u003cbr\u003eo    Hypokalemia, hyperuricemia, hyponatremia\u003cbr\u003eo    Headache, dizziness, postural dizziness, somnolence, vertigo\u003cbr\u003eo    Fatigue, asthenia, facial or peripheral edema, pitting edema\u003cbr\u003eo    Visual disturbances, paraesthesia\u003cbr\u003e•    Cardiovascular:\u003cbr\u003eo    Palpitations, tachycardia, orthostatic hypotension, flushing\u003cbr\u003e•    Gastrointestinal:\u003cbr\u003eo    Abdominal discomfort, upper abdominal pain\u003cbr\u003eo    Nausea, dry mouth, diarrhea, constipation\u003cbr\u003e•    Others:\u003cbr\u003eo    Cough, pharyngolaryngeal pain\u003cbr\u003eo    Rash, erythema\u003cbr\u003eo    Arthralgia, joint swelling, back pain\u003cbr\u003eo    Anorexia, hyperlipidemia, hypercalcemia\u003cbr\u003eo    Coordination issues\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e🔄 Drug Interactions:\u003cbr\u003e•    Antihypertensives – may enhance blood pressure-lowering effect\u003cbr\u003e•    CYP3A4 inhibitors – (e.g. ketoconazole, erythromycin) may increase amlodipine levels\u003cbr\u003e•    CYP3A4 inducers – (e.g. rifampicin, St. John’s Wort) may decrease amlodipine efficacy\u003cbr\u003e•    Grapefruit juice – may raise amlodipine concentration\u003cbr\u003e•    Simvastatin – interaction may increase statin levels\u003cbr\u003e•    NSAIDs – may reduce antihypertensive effect and impair renal function\u003cbr\u003e•    Lithium – risk of lithium toxicity\u003cbr\u003e•    Potassium supplements \/ potassium-sparing diuretics \/ salt substitutes – risk of hyperkalemia\u003cbr\u003e•    Ritonavir, cyclosporine, rifampicin, sildenafil – caution advised\u003cbr\u003e________________________________________\u003cbr\u003e🩺 Indication:\u003cbr\u003e•    Indicated for the treatment of essential hypertension in patients for whom combination therapy is appropriate.\u003cbr\u003e________________________________________\u003cbr\u003e❌ When Not to Use:\u003cbr\u003e•    Hypersensitivity to amlodipine, valsartan, dihydropyridines, or any excipients\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, or cholestasis\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Precautions:\u003cbr\u003e•    Use with caution in patients with renal artery stenosis (unilateral\/bilateral or solitary kidney), as it may increase blood urea nitrogen (BUN) and serum creatinine.\u003cbr\u003e________________________________________\u003cbr\u003e🚨 Warnings:\u003cbr\u003e1. Hyperkalemia Risk\u003cbr\u003e•    Caution when used with potassium-sparing diuretics, potassium supplements, or other agents that raise potassium levels (e.g. heparin).\u003cbr\u003e•    Regular monitoring of potassium is recommended.\u003c\/p\u003e\n\u003cp\u003e2. Not for Hypertensive Crisis\u003cbr\u003e•    Amlodipine has not been proven effective or safe in hypertensive emergencies.\u003cbr\u003e3. Risk of Angioedema\u003cbr\u003e•    Discontinue immediately if angioedema (swelling of face, lips, throat, etc.) occurs.\u003cbr\u003e•    Do not re-administer.\u003cbr\u003e________________________________________\u003cbr\u003e🤰 Pregnancy Category:\u003cbr\u003e•    Always consult your physician.\u003cbr\u003e•    Use during pregnancy is not recommended.\u003cbr\u003e________________________________________\u003cbr\u003e🏠 Storage:\u003cbr\u003eYes – Store at room temperature, away from direct light and heat.\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53318909395275,"sku":null,"price":600.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/images_11.jpg?v=1757058191","url":"https:\/\/wellnesspharmacy.pk\/products\/dioplus-tablets-10-160mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}