{"product_id":"exforge-hct-tablets-10-160-25mg","title":"Exforge HCT Tablets 10\/160\/25mg","description":"\u003cp\u003eMedicine Name: Exforge Hct Tablets 10\/160\/25mg\u003c\/p\u003e\n\u003cp\u003e📋 Exforge HCT Tablets – Specification Sheet\u003cbr\u003e________________________________________\u003cbr\u003e🔒 Requires Prescription\u003cbr\u003eYes\u003cbr\u003e________________________________________\u003cbr\u003e💊 Generics\u003cbr\u003eValsartan + Amlodipine + Hydrochlorothiazide\u003cbr\u003e________________________________________\u003cbr\u003e🩺 Used For\u003cbr\u003eManagement of essential hypertension in adult patients where combination therapy is appropriate.\u003cbr\u003e________________________________________\u003cbr\u003e⚙️ How It Works\u003cbr\u003e•    Valsartan: Blocks angiotensin II receptors → prevents vasoconstriction and aldosterone-mediated sodium retention → lowers blood pressure.\u003cbr\u003e•    Amlodipine: Calcium channel blocker (dihydropyridine) → inhibits calcium influx in vascular smooth muscle and myocardium → causes vasodilation.\u003cbr\u003e•    Hydrochlorothiazide: Thiazide diuretic → inhibits Na⁺\/Cl⁻ symporter in distal renal tubules → increases sodium and water excretion → reduces blood volume and blood pressure.\u003cbr\u003e________________________________________\u003cbr\u003e📈 Indication\u003cbr\u003e•    Indicated for: Treatment of essential hypertension in adults, especially when monotherapy is inadequate.\u003cbr\u003e________________________________________\u003cbr\u003e🚫 When Not to Use\u003cbr\u003e•    Hypersensitivity to valsartan, amlodipine, hydrochlorothiazide, sulphonamides, or dihydropyridines\u003cbr\u003e•    Pregnancy (2nd and 3rd trimester)\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, or cholestasis\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e💡 Precautions\u003cbr\u003e•    Use with caution in patients with:\u003cbr\u003eo    Renal artery stenosis (unilateral or bilateral)\u003cbr\u003eo    Solitary kidney\u003cbr\u003e•    Regularly monitor serum creatinine, urea, and electrolytes\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Warnings\u003cbr\u003e1.    Fetal Risk: Drugs affecting the renin-angiotensin system may impair fetal renal function → oligohydramnios, skeletal deformities, and neonatal death\u003cbr\u003e2.    Symptomatic Hypotension: May occur in volume-depleted or salt-depleted patients; correct before initiating therapy\u003cbr\u003e3.    Renal Impairment: Risk of acute renal failure, especially in susceptible patients\u003cbr\u003e________________________________________\u003cbr\u003e❗ Side Effects\u003cbr\u003e•    Hematologic: Agranulocytosis, leukopenia, thrombocytopenia, hemolytic\/aplastic anemia\u003cbr\u003e•    Metabolic: Hypercalcemia, hyperuricemia, hypokalemia, hyperglycemia, hyperlipidemia, hypomagnesemia\u003cbr\u003e•    Neurological: Headache, hypertonia, visual disturbances\u003cbr\u003e•    Cardiovascular: Arrhythmias (bradycardia, ventricular tachycardia, atrial fibrillation)\u003cbr\u003e•    Electrolyte imbalance: Hypochloremic alkalosis\u003cbr\u003e________________________________________\u003cbr\u003e🔗 Drug Interactions\u003cbr\u003eAmlodipine:\u003cbr\u003e•    CYP3A4 inhibitors (e.g. ketoconazole, erythromycin, verapamil)\u003cbr\u003e•    CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin)\u003cbr\u003e•    Simvastatin, Sildenafil, Immunosuppressants, Grapefruit juice\u003cbr\u003eValsartan:\u003cbr\u003e•    Potassium-sparing diuretics, potassium supplements\u003cbr\u003e•    NSAIDs, Lithium, Rifampicin, Cyclosporine, Ritonavir\u003c\/p\u003e\n\u003cp\u003eHydrochlorothiazide:\u003cbr\u003e•    Metformin, Antidepressants, Antipsychotics\u003cbr\u003e•    Cholestyramine, Cyclosporine, Lithium\u003cbr\u003e•    Alcohol, Beta-blockers, Digitalis glycosides\u003cbr\u003e•    Iodine contrast agents, Amantadine, Cytotoxic agents\u003cbr\u003e________________________________________\u003cbr\u003e💉 Dosage\u003cbr\u003e•    Fixed-dose combination\u003cbr\u003e•    Taken once daily, with or without food\u003cbr\u003e•    Dose strength and regimen depend on individual response and clinical condition\u003cbr\u003e________________________________________\u003cbr\u003e👶 Pregnancy Category\u003cbr\u003e•    Contraindicated in 2nd and 3rd trimester\u003cbr\u003e•    Always consult a physician before use\u003cbr\u003e________________________________________\u003cbr\u003e🧴 Storage\u003cbr\u003eYes\u003cbr\u003e•    Store at room temperature\u003cbr\u003e•    Keep away from direct sunlight, moisture, and excessive heat\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53320401355083,"sku":null,"price":2140.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/27.webp?v=1757069513","url":"https:\/\/wellnesspharmacy.pk\/products\/exforge-hct-tablets-10-160-25mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}