{"product_id":"exforge-hct-tablets-5-160-12-5mg","title":"Exforge HCT Tablets 5\/160\/12.5mg","description":"\u003cp\u003eMedicine Name: Exforge Hct Tablets 5\/160\/12.5mg\u003c\/p\u003e\n\u003cp\u003e📘 Exforge HCT Tablets – Product Specification Sheet\u003cbr\u003e________________________________________\u003cbr\u003e🔒 Requires Prescription\u003cbr\u003eYes\u003cbr\u003e________________________________________\u003cbr\u003e💊 Generic Composition\u003cbr\u003eValsartan + Amlodipine + Hydrochlorothiazide\u003cbr\u003e________________________________________\u003cbr\u003e🩺 Used For\u003cbr\u003eTreatment of Essential Hypertension\u003cbr\u003eParticularly in patients whose blood pressure is not adequately controlled on dual therapy.\u003cbr\u003e________________________________________\u003cbr\u003e⚙️ How It Works\u003cbr\u003e•    Valsartan: An angiotensin II receptor blocker (ARB) that inhibits vasoconstriction and aldosterone effects, lowering blood pressure.\u003cbr\u003e•    Amlodipine: A calcium channel blocker (dihydropyridine) that relaxes vascular smooth muscle by inhibiting calcium influx.\u003cbr\u003e•    Hydrochlorothiazide (HCT): A thiazide diuretic that increases sodium and chloride excretion, reducing plasma volume and contributing to lower blood pressure.\u003cbr\u003e________________________________________\u003cbr\u003e💡 Indication\u003cbr\u003e•    Indicated for the treatment of essential hypertension in adults, especially those requiring triple therapy for adequate blood pressure control.\u003cbr\u003e________________________________________\u003cbr\u003e🚫 When Not to Use\u003cbr\u003e•    Hypersensitivity to valsartan, amlodipine, hydrochlorothiazide, sulfonamide, or dihydropyridine derivatives\u003cbr\u003e•    Pregnancy (2nd and 3rd trimesters)\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, or cholestasis\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Warnings\u003cbr\u003e1.    Fetal Risk: Use of RAS inhibitors (e.g. valsartan) in later pregnancy stages can cause fetal renal dysfunction, oligohydramnios, and skeletal abnormalities.\u003cbr\u003e2.    Symptomatic Hypotension: May occur in salt-\/volume-depleted patients; initiate treatment with caution under supervision.\u003cbr\u003e3.    Renal Function Risk: All three components (especially valsartan and HCT) may alter renal function, leading to acute renal failure in susceptible individuals.\u003cbr\u003e________________________________________\u003cbr\u003e🧪 Precautions\u003cbr\u003e•    Use cautiously in patients with:\u003cbr\u003eo    Unilateral\/bilateral renal artery stenosis\u003cbr\u003eo    Stenosis to a solitary kidney\u003cbr\u003e•    Monitor renal function (urea, creatinine) and electrolyte balance during therapy.\u003cbr\u003e________________________________________\u003cbr\u003e❗ Side Effects\u003cbr\u003e•    Hematologic: Agranulocytosis, bone marrow failure, leukopenia, neutropenia, thrombocytopenia, aplastic anemia\u003cbr\u003e•    Metabolic: Hypokalemia, hyperuricemia, hyperlipidemia, hyperglycemia, hypercalcemia, hypomagnesemia\u003cbr\u003e•    Neurological: Headache, hypertonia, visual disturbance\u003cbr\u003e•    Cardiovascular: Bradycardia, ventricular tachycardia, atrial fibrillation, arrhythmias\u003cbr\u003e•    Others: Anorexia, hypochloremic alkalosis\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e💊 Drug Interactions\u003cbr\u003e•    Amlodipine: Interacts with CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin), inducers (e.g. rifampicin, St. John’s Wort), grapefruit, simvastatin, dantrolene, sildenafil\u003cbr\u003e•    Valsartan: Caution with potassium-sparing diuretics, NSAIDs, lithium, cyclosporine, ritonavir\u003cbr\u003e•    Hydrochlorothiazide: May interact with metformin, carbamazepine, beta-blockers, digitalis glycosides, methyldopa, lithium, alcohol, contrast agents, and cytotoxic drugs\u003cbr\u003e________________________________________\u003cbr\u003e🧴 Storage\u003cbr\u003eYes\u003cbr\u003eStore at room temperature, away from direct light, heat, and moisture.\u003cbr\u003e________________________________________\u003cbr\u003e🤰 Pregnancy Category\u003cbr\u003e⚠️ Not recommended during pregnancy\u003cbr\u003eConsult your physician before use, especially during 2nd or 3rd trimester.\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53319985398091,"sku":null,"price":1870.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_6856.jpg?v=1757065800","url":"https:\/\/wellnesspharmacy.pk\/products\/exforge-hct-tablets-5-160-12-5mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}