{"product_id":"exforge-tablets-10-160mg","title":"Exforge Tablets 10\/160mg","description":"\u003cp\u003eMedicine Name: Exforge Tablets 10\/160mg\u003c\/p\u003e\n\u003cp\u003e📘 Exforge Tablets – Product Specification Sheet\u003cbr\u003e________________________________________\u003cbr\u003e🔒 Requires Prescription\u003cbr\u003eYes\u003cbr\u003e________________________________________\u003cbr\u003e💊 Generic Name\u003cbr\u003eAmlodipine Besilate + Valsartan\u003cbr\u003e________________________________________\u003cbr\u003e🩺 Therapeutic Use\u003cbr\u003eManagement of Hypertension (High Blood Pressure)\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e⚙️ Mechanism of Action\u003cbr\u003e•    Amlodipine: A calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, causing vasodilation and reduced blood pressure.\u003cbr\u003e•    Valsartan: An angiotensin II receptor blocker (ARB) that prevents vasoconstriction and aldosterone secretion, promoting vasodilation.\u003cbr\u003e•    Combined Effect: The combination offers additive antihypertensive effects, reducing blood pressure more effectively than either agent alone.\u003cbr\u003e________________________________________\u003cbr\u003e💡 Indications\u003cbr\u003e•    Indicated for treatment of essential hypertension in adults, especially in patients requiring combination therapy due to inadequate control on monotherapy.\u003cbr\u003e________________________________________\u003cbr\u003e🚫 Contraindications (When Not to Use)\u003cbr\u003e•    Hypersensitivity to amlodipine, valsartan, dihydropyridine derivatives, or any excipients.\u003cbr\u003e•    Severe hepatic impairment, biliary cirrhosis, or cholestasis.\u003cbr\u003e________________________________________\u003cbr\u003e⚠️ Warnings\u003cbr\u003e1.    Hyperkalemia Risk: Caution with potassium-sparing agents, supplements, salt substitutes, and other medications that raise potassium levels (e.g., heparin). Monitor potassium levels regularly.\u003cbr\u003e2.    Not for Hypertensive Crisis: The combination’s safety in acute hypertensive emergencies is not established.\u003cbr\u003e3.    Angioedema: May cause angioedema (especially with valsartan). Discontinue immediately if symptoms occur; do not reinitiate.\u003cbr\u003e________________________________________\u003cbr\u003e🧪 Precautions\u003cbr\u003e•    Use cautiously in patients with:\u003cbr\u003eo    Renal artery stenosis (especially unilateral or single-kidney cases)\u003cbr\u003eo    Renal dysfunction (monitor creatinine and urea)\u003cbr\u003eo    Elderly patients and those on diuretics (risk of hypotension)\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e⚠️ Common Side Effects\u003cbr\u003e•    General: Fatigue, asthenia, facial or peripheral edema\u003cbr\u003e•    Cardiovascular: Hypotension, tachycardia, palpitations, orthostatic hypotension\u003cbr\u003e•    Gastrointestinal: Abdominal discomfort, nausea, diarrhea, constipation, dry mouth\u003cbr\u003e•    Neurological: Dizziness (including postural), somnolence, headache, paraesthesia, visual disturbances\u003cbr\u003e•    Metabolic: Hypokalemia, hyperlipidemia, hyperuricemia, hyponatremia, anorexia\u003cbr\u003e•    Musculoskeletal: Arthralgia, back pain, joint swelling\u003cbr\u003e•    Respiratory: Nasopharyngitis, cough, pharyngolaryngeal pain\u003cbr\u003e•    Skin: Rash, erythema, flushing, hot flush\u003cbr\u003e________________________________________\u003cbr\u003e💊 Drug Interactions\u003cbr\u003eAvoid or monitor with:\u003cbr\u003e•    Other antihypertensives (additive effect)\u003cbr\u003e•    Grapefruit juice (affects amlodipine metabolism)\u003cbr\u003e•    CYP3A4 inhibitors\/inducers (e.g., erythromycin, ketoconazole, rifampicin, St. John’s Wort)\u003cbr\u003e•    Simvastatin (risk of elevated plasma levels)\u003cbr\u003e•    Lithium (risk of toxicity)\u003cbr\u003e•    NSAIDs (may reduce antihypertensive effect)\u003cbr\u003e•    Potassium-altering agents\u003cbr\u003e•    Sildenafil (additive hypotensive effects)\u003cbr\u003e________________________________________\u003cbr\u003e🧴 Storage\u003cbr\u003eYes\u003cbr\u003eStore at room temperature, in a dry place, away from direct heat and light.\u003cbr\u003e________________________________________\u003cbr\u003e🤰 Pregnancy Category\u003cbr\u003e⚠️ Not recommended during pregnancy. Always consult a physician before use.\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53319980089675,"sku":null,"price":3530.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_6858.jpg?v=1757065658","url":"https:\/\/wellnesspharmacy.pk\/products\/exforge-tablets-10-160mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}