{"product_id":"frendol-p-tablets-37-5mg-325mg","title":"Frendol-p Tablets 37.5mg+325mg","description":"\u003cp\u003eMedicine Name: Frendol-p Tablets 37.5mg+325mg\u003c\/p\u003e\n\u003cp\u003eFrendol-P Tablets Specification\u003cbr\u003eRequires Prescription:\u003cbr\u003e✅ Yes\u003cbr\u003e________________________________________\u003cbr\u003eComposition (Generics)\u003cbr\u003e•    Tramadol Hydrochloride\u003cbr\u003e•    Paracetamol (Acetaminophen)\u003cbr\u003e________________________________________\u003cbr\u003eUsed For\u003cbr\u003e•    Treatment of moderate to severe pain\u003cbr\u003e•    Relief from pain \u0026amp; inflammation\u003cbr\u003e________________________________________\u003cbr\u003eHow It Works\u003cbr\u003e•    Tramadol:\u003cbr\u003eActs as a non-selective agonist of µ, δ, and κ opioid receptors (strongest for µ). Also inhibits reuptake of noradrenaline and increases serotonin release. Has antitussive (cough-suppressant) effects.\u003cbr\u003e•    Paracetamol:\u003cbr\u003eBelieved to work centrally by activating descending serotonergic pathways and possibly by inhibiting prostaglandin synthesis or acting via cannabinoid receptors.\u003cbr\u003e________________________________________\u003cbr\u003eDosage\u003cbr\u003e•    Based on the fixed-dose combination of Tramadol HCl + Paracetamol\u003cbr\u003e•    Must be prescribed and supervised by a physician\u003cbr\u003e________________________________________\u003cbr\u003eSide Effects\u003cbr\u003eVery Common (\u0026gt;10%):\u003cbr\u003e•    Nausea\u003cbr\u003e•    Dizziness, drowsiness\u003cbr\u003eCommon (1–10%):\u003cbr\u003e•    Vomiting, constipation, flatulence, diarrhea, stomach pain, dry mouth\u003cbr\u003e•    Sweating (hyperhidrosis), itching\u003cbr\u003e•    Headache, shaking\u003cbr\u003e•    Confusion, mood changes, sleep disorders\u003cbr\u003eUncommon (0.1–1%):\u003cbr\u003e•    Increased heart rate, blood pressure issues\u003cbr\u003e•    Tingling, numbness, muscle twitching, tinnitus\u003cbr\u003e•    Depression, hallucinations, nightmares\u003cbr\u003e•    Breathing difficulty, blood in stools\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003eDrug Interactions\u003cbr\u003eUse caution with:\u003cbr\u003e•    Carbamazepine\u003cbr\u003e•    Opioid agonists\/antagonists: Buprenorphine, Nalbuphine, Pentazocine, Morphine, Codeine\u003cbr\u003e•    CNS depressants: Benzodiazepines, baclofen\u003cbr\u003e•    Antidepressants: SSRIs, MAOIs, Triptans\u003cbr\u003e•    Anticoagulants: Warfarin, Phenprocoumon\u003cbr\u003e•    GI agents: Metoclopramide, Domperidone, Ondansetron\u003cbr\u003e•    Bile acid sequestrants: Cholestyramine\u003cbr\u003e________________________________________\u003cbr\u003eContraindications (When Not to Use)\u003cbr\u003e•    Known allergy to tramadol, paracetamol\u003cbr\u003e•    Acute alcohol poisoning\u003cbr\u003e•    Current use of sedatives, MAO inhibitors, or within 14 days of stopping MAOIs\u003cbr\u003e•    Severe respiratory depression, liver failure, or uncontrolled epilepsy\u003cbr\u003e________________________________________\u003cbr\u003ePrecautions\u003cbr\u003e•    Risk of addiction and misuse with prolonged use\u003cbr\u003e•    Not to be shared with others\u003cbr\u003e•    Overuse can lead to overdose and death\u003cbr\u003e________________________________________\u003cbr\u003eWarnings\u003cbr\u003e1.    Use cautiously in individuals with epilepsy, head injury, or seizures.\u003cbr\u003e2.    Long-term use can cause dependence. Follow tapering instructions from your doctor.\u003cbr\u003e3.    Use with caution if you have liver disease or jaundice symptoms.\u003cbr\u003e________________________________________\u003cbr\u003eAdditional Information\u003cbr\u003e•    Pregnancy Category: Consult a doctor before use.\u003cbr\u003e•    Storage Required: ✅ Yes\u003cbr\u003eStore at room temperature, protected from light and heat.\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53346387263819,"sku":null,"price":210.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_6899.jpg?v=1757399723","url":"https:\/\/wellnesspharmacy.pk\/products\/frendol-p-tablets-37-5mg-325mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}