{"product_id":"glucovance-tablets-2-5-500mg","title":"Glucovance Tablets 2.5\/500mg","description":"\u003cp\u003eMedicine Name: Glucovance Tablets 2.5\/500mg\u003c\/p\u003e\n\u003cp\u003eGlucovance Tablets Specification\u003cbr\u003eRequires Prescription: ✅ Yes\u003cbr\u003e________________________________________\u003cbr\u003eGenerics:\u003cbr\u003eGlibenclamide\u003cbr\u003eMetformin Hydrochloride\u003cbr\u003e________________________________________\u003cbr\u003eUsed For:\u003cbr\u003eManagement of Type 2 Diabetes Mellitus\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eHow It Works:\u003cbr\u003eMetformin Hydrochloride reduces both fasting and postprandial blood glucose by:\u003cbr\u003eDecreasing hepatic glucose production\u003cbr\u003eReducing intestinal glucose absorption\u003cbr\u003eEnhancing insulin sensitivity\u003cbr\u003eGlibenclamide (a sulfonylurea) lowers blood glucose by:\u003cbr\u003eStimulating insulin release from pancreatic β-cells\u003cbr\u003eRequires functioning pancreatic cells\u003cbr\u003eTogether, they improve glycemic control through complementary mechanisms.\u003cbr\u003e________________________________________\u003cbr\u003eDosage:\u003cbr\u003eContains a fixed-dose combination of Glibenclamide and Metformin HCl\u003cbr\u003eTo be used under medical supervision, with individualized dosing\u003cbr\u003e________________________________________\u003cbr\u003eSide Effects:\u003cbr\u003eDiarrhea\u003cbr\u003eHeadache\u003cbr\u003eNausea \/ Vomiting\u003cbr\u003eAbdominal pain\u003cbr\u003eDizziness\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eDrug Interactions:\u003cbr\u003eMay increase blood glucose:\u003cbr\u003eThiazide diuretics\u003cbr\u003eCorticosteroids\u003cbr\u003ePhenothiazines\u003cbr\u003eEstrogens, oral contraceptives\u003cbr\u003eThyroid products\u003cbr\u003ePhenytoin\u003cbr\u003eNicotinic acid\u003cbr\u003eCalcium channel blockers\u003cbr\u003eSympathomimetics\u003cbr\u003eIsoniazid\u003cbr\u003eMetformin has minimal protein binding, making it less prone to interaction.\u003cbr\u003eGlibenclamide is highly protein-bound, increasing interaction risk with similar drugs (e.g., salicylates, sulfonamides, chloramphenicol, probenecid).\u003cbr\u003e________________________________________\u003cbr\u003eIndication:\u003cbr\u003eFirst-line therapy: In combination with diet and exercise when monotherapy is inadequate\u003cbr\u003eSecond-line therapy: When monotherapy with sulfonylurea or Metformin fails\u003cbr\u003e________________________________________\u003cbr\u003eWhen Not to Use (Contraindications):\u003cbr\u003eDo not use in patients with:\u003cbr\u003eRenal impairment (Creatinine ≥1.5 mg\/dL in males, ≥1.4 mg\/dL in females)\u003cbr\u003eCongestive heart failure requiring drug treatment\u003cbr\u003eHypersensitivity to Metformin or Glibenclamide\u003cbr\u003eMetabolic acidosis (including diabetic ketoacidosis)\u003cbr\u003eAcute conditions such as myocardial infarction, shock, septicemia\u003cbr\u003e________________________________________\u003c\/p\u003e\n\u003cp\u003ePrecaution:\u003cbr\u003eRisk of hypoglycemia: Ensure appropriate dosing and patient education\u003cbr\u003eMonitor renal and liver function regularly\u003cbr\u003e________________________________________\u003cbr\u003eWarnings:\u003cbr\u003eWarning 1:\u003cbr\u003eRenal or hepatic insufficiency can elevate drug levels and increase hypoglycemia risk.\u003cbr\u003eWarning 2:\u003cbr\u003eElderly, malnourished, or those with adrenal\/pituitary insufficiency or alcohol use are at higher risk for hypoglycemia—may have masked symptoms.\u003cbr\u003eWarning 3:\u003cbr\u003eNot recommended for use in children, as safety and effectiveness are not established.\u003cbr\u003e________________________________________\u003cbr\u003eAdditional Information:\u003cbr\u003ePregnancy Category:\u003cbr\u003eConsult a physician before use.\u003cbr\u003eStorage Required: ✅ Yes\u003cbr\u003eStore at room temperature, away from light and heat\u003cbr\u003e\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53346531672395,"sku":null,"price":160.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_6905.jpg?v=1757400441","url":"https:\/\/wellnesspharmacy.pk\/products\/glucovance-tablets-2-5-500mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}