{"product_id":"novoteph-capsules-20mg","title":"Novoteph Capsules 20MG","description":"\u003cp\u003eMedicine Name: Novoteph Capsules 20mg\u003cbr\u003eNovoteph Capsules Specification\u003cbr\u003eRequires Prescription\u003cbr\u003eYes\u003cbr\u003eGeneric Composition\u003cbr\u003e Esomeprazole\u003cbr\u003eTherapeutic Use\u003cbr\u003eIndicated For the Treatment of:\u003cbr\u003e Heartburn\u003cbr\u003e Gastroesophageal Reflux Disease (GERD)\u003cbr\u003e Gastritis\u003cbr\u003e Peptic Ulcers\u003cbr\u003e Acid-related disorders\u003cbr\u003eMechanism of Action\u003cbr\u003eEsomeprazole is a proton pump inhibitor (PPI) that acts by irreversibly binding to the H⁺\/K⁺\u003cbr\u003eATPase enzyme in gastric parietal cells.\u003cbr\u003e This enzyme system is the final step in acid production.\u003cbr\u003e Inhibition results in a profound and long-lasting reduction in gastric acid secretion,\u003cbr\u003eleading to increased gastric pH and symptom relief.\u003cbr\u003eDosage\u003cbr\u003e As prescribed by the physician\u003cbr\u003e Usual adult dose: 20–40 mg once daily, depending on indication and patient response\u003cbr\u003eSide Effects\u003cbr\u003eCommon:\u003cbr\u003e Headache\u003cbr\u003e Gastrointestinal disturbances: Nausea, abdominal discomfort, diarrhea, constipation\u003cbr\u003e Skin reactions\u003cbr\u003e Dry mouth\u003cbr\u003eRare:\u003cbr\u003e Angioedema\u003cbr\u003e Anaphylaxis\u003cbr\u003e Fundic gland polyps (especially with long-term use)\u003cbr\u003eDrug Interactions\u003cbr\u003eEsomeprazole may interact with:\u003cbr\u003e Antiepileptics: Phenytoin\u003cbr\u003e Anticoagulants: Warfarin\u003cbr\u003e Antiplatelets: Clopidogrel (avoid concurrent use)\u003cbr\u003e Antifungals: Ketoconazole, itraconazole, voriconazole\u003cbr\u003e CNS agents: Diazepam, citalopram, imipramine, clomipramine\u003cbr\u003e Immunosuppressants: Tacrolimus\u003cbr\u003e Cardiac agents: Digoxin\u003cbr\u003e Chemotherapy: Methotrexate\u003cbr\u003e CYP3A4 inhibitors\/inducers (e.g., rifampicin, St. John's Wort)\u003cbr\u003e Others: Erlotinib\u003cbr\u003eContraindications\u003cbr\u003e Known hypersensitivity to esomeprazole or other proton pump inhibitors\u003cbr\u003e Severe allergic reactions such as:\u003cbr\u003eo Angioedema\u003cbr\u003eo Anaphylaxis\u003cbr\u003eo Bronchospasm\u003cbr\u003eo Acute interstitial nephritis\u003cbr\u003eo Urticaria\u003cbr\u003ePrecautions\u003cbr\u003e Vitamin B12 Deficiency Risk: Long-term daily use (\u0026gt;3 years) may impair\u003cbr\u003ecyanocobalamin (B12) absorption.\u003cbr\u003e Monitor B12 levels in patients at risk.\u003cbr\u003eWarnings\u003cbr\u003e1. Hypomagnesemia: Rare but serious cases reported with prolonged use. Consider\u003cbr\u003eperiodic monitoring.\u003cbr\u003e2. Osteoporosis-related Fractures: Long-term\/high-dose PPI therapy may increase risk of\u003cbr\u003efractures (hip, wrist, spine), especially in elderly or those with other risk factors.\u003cbr\u003e3. Clopidogrel Interaction: Avoid co-administration due to possible reduction in\u003cbr\u003eclopidogrel’s antiplatelet effect.\u003cbr\u003ePregnancy Category\u003cbr\u003e Consult your physician before using during pregnancy or breastfeeding.\u003cbr\u003eStorage\u003cbr\u003eYes\u003cbr\u003e Store at room temperature, away from direct sunlight and heat.\u003c\/p\u003e","brand":"The Wellness Hospital","offers":[{"title":"Default Title","offer_id":53280668483915,"sku":null,"price":275.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/5711\/6491\/files\/JA1_7221.jpg?v=1756546968","url":"https:\/\/wellnesspharmacy.pk\/products\/novoteph-capsules-20mg","provider":"The Wellness Hospital","version":"1.0","type":"link"}