Co-Diovan Tablets 80mg/12.5mg

Medicine Name: Co-Diovan Tablets 80mg/12.5mg

📄 Co-Diovan Tablets – Product Specification
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Requires Prescription:
✅ Yes
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Generics:
Valsartan + Hydrochlorothiazide
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Used For:
•    Hypertension (to lower blood pressure)
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How It Works:
Valsartan:
•    Blocks angiotensin II from binding to the AT1 receptor in tissues like vascular smooth muscle and adrenal glands.
•    This prevents vasoconstriction and aldosterone secretion, reducing blood pressure.
•    Its effect is independent of angiotensin II synthesis pathway.
Hydrochlorothiazide:
•    A thiazide diuretic that increases sodium and chloride excretion, leading to reduced plasma volume.
•    This results in increased renin activity, aldosterone secretion, potassium loss, and reduced serum potassium.
•    The exact mechanism of its antihypertensive effect is not fully known.
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Usage and Safety
Dosage:
•    Valsartan + Hydrochlorothiazide (Exact dose based on physician’s prescription)
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Side Effects:
Uncommon:
•    Dehydration
•    Paresthesia
•    Blurred vision
•    Tinnitus
•    Hypotension
•    Cough
•    Myalgia
•    Fatigue
Very Rare:
•    Dizziness
•    Diarrhea
•    Arthralgia
Frequency Not Known:
•    Syncope
•    Non-cardiogenic pulmonary edema
•    Impaired renal function
•    Elevated serum uric acid, bilirubin, creatinine
•    Hypokalemia
•    Hyponatremia
•    Elevated blood urea nitrogen (BUN)
•    Neutropenia
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Drug Interactions:
Use caution with:
•    Lithium
•    Rifampin, ciclosporin, ritonavir
•    Antidepressants, antipsychotics, antiepileptics
•    Allopurinol, noradrenaline, methyldopa
•    Atropine, biperiden
•    Cholestyramine, colestipol
•    Probenecid, sulfinpyrazone
•    Potassium, kaliuretic diuretics
•    Tetracyclines, carbamazepine
•    Alcohol, anesthetics, sedatives
•    Penicillin G, salicylates, antiarrhythmics
•    Cyclosporine
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Indication:
•    Management of essential hypertension where combination therapy is appropriate
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When Not to Use:
Contraindicated in:
•    Hypersensitivity to Valsartan, Hydrochlorothiazide, or sulfonamide-derived drugs
•    Severe hepatic impairment, biliary cirrhosis, cholestasis
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Precautions:
•    Use caution in volume- or salt-depleted patients (e.g., on high-dose diuretics)
•    Monitor blood pressure closely; symptomatic hypotension may occur
•    May need to correct volume status before starting therapy
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Warnings:
🔴 Warning 1:
Photosensitivity may occur with thiazides. If present, discontinue and consider sun protection if re-administered.
🔴 Warning 2:
Allergic reactions may occur with hydrochlorothiazide in patients with history of asthma or allergy.
🔴 Warning 3:
Hydrochlorothiazide can alter glucose tolerance and elevate cholesterol/triglycerides.
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Pregnancy Category:
⚠️ Always consult a physician before use, especially during pregnancy.
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Storage:
✅ Yes – Store at room temperature, away from light and heat