Diampa Lt Tablets 10mg+5mg

Medicine Name: Diampa Lt Tablets 10mg+5mg

💊 Diampa LT Tablets – Product Specification
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✅ Requires Prescription:
Yes
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🔬 Generics:
Empagliflozin + Linagliptin
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🩺 Used For:
Type 2 Diabetes Mellitus
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⚙️ How It Works:
•    Empagliflozin (SGLT2 Inhibitor):
Blocks sodium-glucose co-transporter 2 in the kidneys, lowering the renal glucose threshold and increasing glucose excretion through urine.
→ Result: Decreases blood glucose levels.
•    Linagliptin (DPP-4 Inhibitor):
Inhibits DPP-4 enzyme, preventing degradation of incretin hormones (GLP-1 & GIP).
→ Result: Increases insulin release and reduces glucagon secretion in a glucose-dependent manner, helping regulate blood sugar levels.
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📦 Dosage:
Empagliflozin + Linagliptin
Dose must be individualized and prescribed by a healthcare professional.
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⚠️ Side Effects:
•    Common:
o    Urinary tract infections (including pyelonephritis and urosepsis)
o    Genital infections (vaginal moniliasis, balanitis, vulvovaginitis)
o    Nasopharyngitis
o    Hypoglycemia (with insulin or sulphonylurea)
o    Increased urination, thirst, cough, pruritus, rash
o    Elevated amylase/lipase
•    Uncommon:
o    Hypersensitivity reactions, angioedema, urticaria
o    Pancreatitis
o    Volume depletion, dysuria
o    Increased hematocrit, serum lipids, and creatinine
•    Rare/Not Known:
o    Fournier’s gangrene (necrotizing fasciitis of the perineum)
o    Bullous pemphigoid
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🔄 Drug Interactions:
•    Diuretics:
↑ Risk of volume depletion and renal impairment
•    1,5-AG Assay Interference:
Not reliable for glycemic monitoring in patients taking SGLT2 inhibitors
→ Use alternate methods (e.g., HbA1c)
•    CYP3A4/P-gp Inducers (e.g., Rifampin):
May ↓ Linagliptin effectiveness
→ Use alternative therapy if coadministered
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🩹 Indications:
•    As adjunct to diet and exercise in adults with Type 2 Diabetes Mellitus:
o    When monotherapy (with Empagliflozin or Linagliptin) is insufficient
o    When already stabilized on the free combination of the two agents
•    Empagliflozin is also indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes and established CVD
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🚫 When Not to Use:
•    Hypersensitivity to:
o    Empagliflozin
o    Linagliptin
o    Other SGLT2 or DPP-4 inhibitors
•    Patients with allergy to any excipients
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🛡️ Precautions:
•    Pancreatitis Risk:
Discontinue immediately if suspected; do not restart if confirmed
→ Caution in patients with a history of pancreatitis
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🚨 Warnings:
1.    Hypotension Risk:
Use caution in patients with:
o    Cardiovascular disease
o    Elderly (≥75 years)
o    Diuretics or antihypertensives
2.    Amputation Risk:
↑ Risk of lower limb amputation (primarily toes)
→ Emphasize routine foot care for diabetic patients
3.    UTI Risk:
SGLT2 inhibitors increase risk of urinary tract infections
→ Evaluate and treat promptly
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🤰 Pregnancy Category:
Always consult your physician before use during pregnancy or breastfeeding.
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🏠 Storage:
Yes – Store at room temperature, away from direct light and heat.