Diampa-M Tablets 5mg+500mg

Medicine Name: Diampa-M Tablets 5mg/500mg

💊 Diampa-M Tablets – Product Specification
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✅ Requires Prescription:
Yes
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🔬 Generics:
Empagliflozin + Metformin HCl
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🩺 Used For:
Type 2 Diabetes Mellitus
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⚙️ How It Works:
•    Empagliflozin (SGLT2 Inhibitor):
Inhibits sodium-glucose co-transporter 2 in the kidneys, reducing glucose reabsorption and increasing urinary glucose excretion.
→ Result: Lowers blood glucose levels.
•    Metformin HCl (Biguanide):
o    Reduces hepatic glucose production
o    Improves insulin sensitivity
o    Enhances peripheral glucose uptake
o    Decreases intestinal glucose absorption
→ Result: Improves glycemic control without increasing insulin secretion.
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📦 Dosage:
Empagliflozin + Metformin HCl
Dosage is individualized based on patient needs and existing therapy.
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⚠️ Side Effects:
•    Empagliflozin-related (≥5% incidence):
o    Urinary tract infections
o    Female genital mycotic infections
•    Metformin-related (>5% incidence):
o    Diarrhea
o    Nausea/vomiting
o    Flatulence
o    Abdominal discomfort
o    Indigestion
o    Asthenia
o    Headache
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🔄 Drug Interactions:
•    Diuretics: Risk of dehydration and hypotension
•    1,5-AG Assay Interference: Not reliable for glycemic control monitoring
•    Other Interacting Drugs:
o    Ranolazine, vandetanib, dolutegravir, cimetidine (renal function impact)
o    Zonisamide, acetazolamide, dichlorphenamide (↑ risk of lactic acidosis)
o    Corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, isoniazid, nifedipine (may affect glucose regulation)
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🩹 Indication:
Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus:
•    Inadequately controlled on empagliflozin or metformin alone
•    Already stabilized on the free combination of empagliflozin and metformin
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🚫 When Not to Use:
•    Severe renal impairment, ESRD, or dialysis
•    Metabolic acidosis, including diabetic ketoacidosis
•    Hypersensitivity to empagliflozin, metformin, or any excipients
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🛡️ Precautions:
•    Store in a cool, dry place, away from direct heat and light
•    Keep out of reach of children
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🚨 Warnings:
1.    Lactic Acidosis (Metformin-related):
o    Rare but life-threatening
o    Symptoms: malaise, myalgia, abdominal pain, respiratory distress
o    Severe cases may lead to hypothermia, hypotension, and cardiac issues
2.    Hypotension (Empagliflozin-related):
o    Especially in elderly, patients with renal impairment or low BP
o    Assess and correct volume status before initiating therapy
3.    Ketoacidosis:
o    Rare but serious and potentially fatal
o    Reported in patients with both type 1 and type 2 diabetes
o    Not indicated for patients with type 1 diabetes
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🤰 Pregnancy Category:
Consult your physician before use during pregnancy or breastfeeding
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🏠 Storage:
Yes – Store at room temperature, protected from direct light and heat