Medicine Name: Dioplus Tablets 10/160mg
📄 Dioplus Tablets – Product Specification
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📌 Requires Prescription:
Yes
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🧪 Generics:
Amlodipine Besilate + Valsartan
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💉 Used For:
Treatment of Hypertension (high blood pressure)
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⚙️ How It Works:
• Amlodipine is a calcium channel blocker that relaxes vascular smooth muscle, reducing peripheral resistance.
• Valsartan is an angiotensin II receptor blocker (ARB) that prevents vasoconstriction and aldosterone secretion.
• Their complementary mechanisms produce an additive antihypertensive effect, offering improved blood pressure control compared to either drug alone.
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💊 Dosage:
Amlodipine Besilate + Valsartan
(Dosage must be prescribed by a qualified healthcare professional based on patient-specific factors.)
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⚠️ Side Effects:
• Common:
o Nasopharyngitis, influenza
o Hypokalemia, hyperuricemia, hyponatremia
o Headache, dizziness, postural dizziness, somnolence, vertigo
o Fatigue, asthenia, facial or peripheral edema, pitting edema
o Visual disturbances, paraesthesia
• Cardiovascular:
o Palpitations, tachycardia, orthostatic hypotension, flushing
• Gastrointestinal:
o Abdominal discomfort, upper abdominal pain
o Nausea, dry mouth, diarrhea, constipation
• Others:
o Cough, pharyngolaryngeal pain
o Rash, erythema
o Arthralgia, joint swelling, back pain
o Anorexia, hyperlipidemia, hypercalcemia
o Coordination issues
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🔄 Drug Interactions:
• Antihypertensives – may enhance blood pressure-lowering effect
• CYP3A4 inhibitors – (e.g. ketoconazole, erythromycin) may increase amlodipine levels
• CYP3A4 inducers – (e.g. rifampicin, St. John’s Wort) may decrease amlodipine efficacy
• Grapefruit juice – may raise amlodipine concentration
• Simvastatin – interaction may increase statin levels
• NSAIDs – may reduce antihypertensive effect and impair renal function
• Lithium – risk of lithium toxicity
• Potassium supplements / potassium-sparing diuretics / salt substitutes – risk of hyperkalemia
• Ritonavir, cyclosporine, rifampicin, sildenafil – caution advised
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🩺 Indication:
• Indicated for the treatment of essential hypertension in patients for whom combination therapy is appropriate.
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❌ When Not to Use:
• Hypersensitivity to amlodipine, valsartan, dihydropyridines, or any excipients
• Severe hepatic impairment, biliary cirrhosis, or cholestasis
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⚠️ Precautions:
• Use with caution in patients with renal artery stenosis (unilateral/bilateral or solitary kidney), as it may increase blood urea nitrogen (BUN) and serum creatinine.
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🚨 Warnings:
1. Hyperkalemia Risk
• Caution when used with potassium-sparing diuretics, potassium supplements, or other agents that raise potassium levels (e.g. heparin).
• Regular monitoring of potassium is recommended.
2. Not for Hypertensive Crisis
• Amlodipine has not been proven effective or safe in hypertensive emergencies.
3. Risk of Angioedema
• Discontinue immediately if angioedema (swelling of face, lips, throat, etc.) occurs.
• Do not re-administer.
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🤰 Pregnancy Category:
• Always consult your physician.
• Use during pregnancy is not recommended.
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🏠 Storage:
Yes – Store at room temperature, away from direct light and heat.
