Dioplus Tablets 5/160mg

Medicine Name: Dioplus Tablets 5/160mg
💊 Dioplus Tablets – Product Specification
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✅ Requires Prescription:
Yes
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🧪 Generics:
Amlodipine Besilate + Valsartan
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🎯 Used For:
•    Management of Hypertension (High Blood Pressure)
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⚙️ How It Works:
•    Amlodipine is a calcium channel blocker that dilates blood vessels and improves blood flow.
•    Valsartan is an angiotensin II receptor blocker (ARB) that prevents vasoconstriction.
•    The combination of both drugs offers additive antihypertensive effects, controlling blood pressure more effectively than either alone.
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💊 Dosage:
•    Contains Amlodipine Besilate + Valsartan
(Use as prescribed by a healthcare professional.)
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⚠️ Side Effects:
•    Common:
o    Nasopharyngitis, influenza
o    Headache, fatigue, asthenia
o    Facial and peripheral edema, flushing, hot flushes
o    Dizziness (including postural), somnolence, visual disturbances
o    Hypokalemia, hyponatremia, hyperuricemia
•    Gastrointestinal:
o    Abdominal discomfort, upper abdominal pain
o    Constipation, diarrhea, dry mouth, nausea
•    Musculoskeletal and Others:
o    Arthralgia, back pain, joint swelling
o    Paraesthesia, rash, erythema
•    Cardiovascular:
o    Palpitations, tachycardia, orthostatic hypotension
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🔄 Drug Interactions:
•    CYP3A4 inhibitors (e.g. protease inhibitors, azole antifungals, erythromycin, verapamil)
•    CYP3A4 inducers (e.g. rifampicin, St. John’s Wort)
•    Simvastatin, Sildenafil, Lithium
•    NSAIDs, potassium-sparing diuretics, potassium supplements
•    Grapefruit juice (increases amlodipine levels)
•    Other antihypertensives — additive effect
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💡 Indication:
•    Indicated for the treatment of essential hypertension in patients where combination therapy is appropriate.
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🚫 When Not to Use:
•    Hypersensitivity to amlodipine, valsartan, dihydropyridine derivatives, or any excipient
•    Severe hepatic impairment, biliary cirrhosis, or cholestasis
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⚠️ Precautions:
•    Use cautiously in patients with renal artery stenosis (unilateral/bilateral or in a solitary kidney) as it may cause elevated blood urea and creatinine levels.
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🚨 Warnings:
Warning 1:
•    Use with potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may lead to hyperkalemia. Monitor potassium levels closely.
Warning 2:
•    Not recommended in cases of hypertensive crisis — safety and efficacy not established.
Warning 3:
•    Angioedema (swelling of face, lips, tongue, or throat) may occur. If this develops, discontinue immediately and do not re-administer.
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🤰 Pregnancy Category:
•    Always consult your physician before using this medicine. Use during pregnancy is not recommended.
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🏠 Storage:
✅ Yes – Store at room temperature, protected from direct light and heat.