Dioplus Tablets 5/80mg

Medicine Name: Dioplus Tablets 5/80mg

💊 Dioplus Tablets – Product Specification
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📋 Requires Prescription:
✅ Yes
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🧪 Generics:
Amlodipine Besilate + Valsartan
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🎯 Used For:
•    Hypertension (High Blood Pressure)
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⚙️ How It Works:
•    Amlodipine is a calcium channel blocker that relaxes blood vessels and improves blood flow.
•    Valsartan is an angiotensin II receptor blocker (ARB) that prevents blood vessels from narrowing.
•    Together, they have complementary mechanisms and a stronger blood pressure–lowering effect than when used alone.
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💊 Dosage:
•    Amlodipine Besilate + Valsartan
(Use as prescribed by a healthcare professional.)
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⚠️ Side Effects:
•    Common:
o    Nasopharyngitis, influenza
o    Hypokalemia, headache, fatigue, asthenia
o    Facial edema, peripheral edema, flushing, hot flushes, pitting edema
o    Abdominal discomfort, constipation, diarrhea, nausea, dry mouth
•    Uncommon to Rare:
o    Visual impairment, dizziness (including postural), paraesthesia, somnolence
o    Palpitations, tachycardia, orthostatic hypotension
o    Back pain, joint swelling, arthralgia
o    Rash, erythema
•    Metabolic:
o    Hypercalcemia, hyperlipidemia, hyperuricemia, hyponatremia
o    Anorexia
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🔄 Drug Interactions:
•    CYP3A4 inhibitors: Protease inhibitors, azole antifungals, macrolides (e.g. erythromycin, clarithromycin), verapamil, diltiazem
•    CYP3A4 inducers: Rifampicin, St. John’s Wort (Hypericum perforatum)
•    Others:
o    Simvastatin
o    NSAIDs
o    Lithium
o    Sildenafil
o    Potassium supplements or potassium-sparing diuretics
o    Grapefruit juice (increases amlodipine levels)
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💡 Indication:
•    Treatment of essential hypertension (high blood pressure not caused by another condition).
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❌ When Not to Use:
•    Known hypersensitivity to amlodipine, valsartan, or any excipients
•    Severe hepatic impairment, biliary cirrhosis, or cholestasis
•    Allergy to dihydropyridine derivatives
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⚠️ Precautions:
•    Use cautiously in patients with renal artery stenosis, as blood urea and creatinine levels may rise.
•    Monitor kidney function and electrolytes in at-risk patients.
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🚨 Warnings:
Warning 1:
•    Risk of hyperkalemia when used with potassium supplements, potassium-sparing diuretics, or potassium-containing salt substitutes. Monitor potassium levels closely.
Warning 2:
•    Not recommended for use in hypertensive crisis as safety and efficacy are unproven.
Warning 3:
•    Angioedema (face, lips, tongue, throat swelling) may occur. Stop immediately if symptoms develop. Do not restart therapy in affected patients.
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👶 Pregnancy Category:
•    Consult your doctor before use. Not recommended during pregnancy.
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🏠 Storage:
✅ Yes — Store at room temperature, away from direct sunlight and heat.