Duragesic Forte Tablets 650mg/50mg

Medicine Name: Duragesic Forte Tablets 650mg/50mg

💊 Duragesic Forte – Product Specification Sheet
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✅ Requires Prescription
Yes
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🧪 Generic Composition
•    Paracetamol
•    Orphenadrine Citrate
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🩺 Used For
Muscle Relaxant
Primarily used for relief of pain and discomfort in muscle spasm conditions, especially those associated with tension headaches, neck and back strain, and musculoskeletal injuries.
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⚙️ Mechanism of Action
•    Orphenadrine Citrate:
A centrally acting skeletal muscle relaxant with anticholinergic properties. It relieves pain from muscle spasms by acting on the central nervous system.
•    Paracetamol:
An analgesic (pain reliever) and antipyretic (fever reducer). It works by inhibiting prostaglandin synthesis in the brain, thereby reducing pain and fever.
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📦 Dosage
Paracetamol + Orphenadrine Citrate
(Follow physician instructions. Not to exceed prescribed dosage.)
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⚠️ Side Effects
Orphenadrine Citrate
•    Common: Dry mouth, tachycardia, palpitations, urinary retention, blurred vision, pupil dilation, dizziness, drowsiness, nausea, constipation, weakness
•    Less Common: Sedation, rash, allergic reactions, confusion (especially in elderly)
•    Rare: Aplastic anemia
Paracetamol
•    Uncommon: Nausea, dyspepsia, allergic skin reactions, blood disorders (very rare)
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🔄 Drug Interactions
•    Phenothiazines
•    Metoclopramide
•    Anticholinergic agents (e.g., propantheline, tricyclic antidepressants, opioids)
•    Alcohol or anticonvulsants (may increase liver toxicity risk with paracetamol)
•    Other paracetamol or orphenadrine-containing products (avoid duplication)
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🎯 Indications
•    Tension-type headaches, particularly those involving muscle spasm in the head and neck
•    Acute musculoskeletal pain, including:
o    Sprains and strains
o    Whiplash injuries
o    Acute torticollis
o    Prolapsed intervertebral disc
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🚫 Contraindications (When Not to Use)
•    Glaucoma
•    Prostatic hypertrophy or bladder neck obstruction
•    Myasthenia gravis
•    Oesophageal or gastrointestinal obstruction (pyloric or duodenal)
•    Hypersensitivity to paracetamol or orphenadrine citrate
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⚠️ Warnings
1.    Cardiac Conditions:
Use with caution in patients with tachycardia, decompensated heart failure, coronary artery disease, or arrhythmias.
2.    Hepatic/Renal Impairment:
Paracetamol requires caution in patients with liver or kidney dysfunction to prevent toxicity.
3.    Long-term Use:
Continuous use of orphenadrine is not recommended without monitoring. Long-term therapy should include regular blood, liver, and urine tests.
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🛡️ Precaution
Avoid combination with other products containing paracetamol or orphenadrine to reduce risk of overdose or adverse effects.
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🤰 Pregnancy Category
Always consult your doctor before using during pregnancy or lactation.
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🧊 Storage
Yes — Store at room temperature, protected from direct heat, light, and moisture.