Duragesic Tablets 35mg/450mg

Medicine Name: Duragesic Tablets 35mg/450mg

💊 Duragesic Tablets – Product Specification Sheet
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✅ Requires Prescription
Yes
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🧪 Generic Composition
•    Paracetamol
•    Orphenadrine Citrate
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🩺 Used For
Muscle Relaxant
Relief of pain and discomfort associated with muscle spasms, tension headaches, traumatic musculoskeletal conditions, and spasmodic conditions of the head, neck, limbs, and trunk.
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⚙️ Mechanism of Action
•    Orphenadrine Citrate:
A centrally acting skeletal muscle relaxant with mild anticholinergic properties. It works by relieving muscle spasms and associated pain.
•    Paracetamol (Acetaminophen):
An analgesic and antipyretic that helps reduce pain and fever by inhibiting prostaglandin synthesis in the central nervous system.
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📦 Dosage
Paracetamol + Orphenadrine Citrate
(Use as directed by the physician. Dosage may vary depending on the condition and patient response.)
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⚠️ Side Effects
Orphenadrine Citrate
•    Common: Dry mouth, blurred vision, drowsiness, dizziness, headache, tachycardia, palpitations, nausea, constipation, urinary retention
•    Less Common: Skin rash, sedation, allergic reactions, mental confusion (especially in the elderly)
•    Rare: Aplastic anemia (very rare)
Paracetamol
•    Generally well tolerated
•    Possible reactions: Nausea, dyspepsia, allergic reactions, and rare hematological disturbances
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🔄 Drug Interactions
•    Phenothiazines
•    Metoclopramide
•    Anticholinergic agents (e.g. propantheline, tricyclic antidepressants, narcotics)
•    Alcohol and anticonvulsants (may increase risk of liver damage with paracetamol)
•    Other medicines containing paracetamol or orphenadrine — avoid concurrent use
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🎯 Indications
•    Tension headaches and occipital headaches with skeletal muscle spasm
•    Acute musculoskeletal conditions such as:
o    Sprains and strains
o    Whiplash injuries
o    Acute torticollis
o    Prolapsed intervertebral disc
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🚫 Contraindications (When Not to Use)
•    Glaucoma
•    Prostatic hypertrophy or bladder neck obstruction
•    Myasthenia gravis
•    Oesophageal spasm or pyloric/duodenal obstruction
•    Hypersensitivity to paracetamol or orphenadrine citrate
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🛑 Warnings
1.    Cardiac Conditions (Orphenadrine):
Use with caution in patients with tachycardia, heart failure, coronary artery disease, or arrhythmias.
2.    Hepatic/Renal Impairment (Paracetamol):
Caution in patients with liver or kidney dysfunction. Risk of hepatotoxicity with overdose or prolonged use.
3.    Long-term Use (Orphenadrine):
Long-term safety not established. Periodic monitoring of liver function, urine, and blood tests is advised for prolonged therapy.
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⚠️ Precaution
Avoid concurrent use of other medicines containing paracetamol or orphenadrine to prevent overdose or adverse effects.
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🤰 Pregnancy Category
Always consult a physician before use during pregnancy or breastfeeding.
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🧊 Storage
Yes — Store at room temperature, away from heat, moisture, and direct light.