Elzanor Tablets 12.5mg/500mg

Medicine Name: Elzanor Tablets 12.5/500mg
Elzanor Tablets Specification
Requires Prescription: Yes
Generics:
•    Empagliflozin (12.5 mg)
•    Metformin Hydrochloride (500 mg)
Used For:
•    Management of Type 2 Diabetes Mellitus
________________________________________
How It Works
•    Metformin Hydrochloride is a biguanide class antihyperglycemic agent that lowers both fasting and post-meal blood glucose levels. It works by:
o    Decreasing hepatic glucose production
o    Reducing glucose absorption in the intestine
o    Enhancing insulin sensitivity and peripheral glucose uptake
•    Empagliflozin is an SGLT2 inhibitor that lowers blood sugar by:
o    Inhibiting glucose reabsorption in the kidney
o    Increasing urinary glucose excretion
Together, these drugs work synergistically to improve glycemic control in patients with type 2 diabetes.
________________________________________
Indication
Elzanor is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus:
•    Inadequately controlled with metformin or empagliflozin alone
•    Already receiving both drugs separately
________________________________________
Usage and Safety
Dosage:
Empagliflozin 12.5 mg + Metformin HCl 500 mg
Dose should be individualized based on the patient’s current regimen, renal function, and glycemic control targets.
________________________________________
Side Effects
Empagliflozin-related:
•    Urinary tract infections
•    Genital fungal infections (especially in females)
Metformin-related:
•    Diarrhea, nausea, vomiting
•    Flatulence, abdominal discomfort
•    Headache, weakness (asthenia)
•    Metallic taste
________________________________________
Drug Interactions
•    Diuretics (increased risk of volume depletion)
•    Cimetidine and drugs that affect renal function
•    Oral contraceptives, thyroid products, steroids
•    NSAIDs, phenytoin, calcium channel blockers
•    Nifedipine may increase metformin absorption
•    Ranolazine, dolutegravir, vandetanib (affect renal clearance)
________________________________________
Contraindications (When Not to Use)
•    Severe renal impairment, end-stage renal disease (ESRD), or dialysis
•    Metabolic acidosis, including diabetic ketoacidosis
•    Known hypersensitivity to either ingredient
________________________________________
Precautions
•    Keep away from children
•    Use with caution in elderly or dehydrated patients
•    Regular monitoring of renal function is advised
•    Not recommended for type 1 diabetes mellitus
________________________________________
Warnings
1. Lactic Acidosis:
•    Rare but serious; early symptoms include malaise, muscle pain, abdominal pain, drowsiness, or breathing issues.
2. Hypotension:
•    Due to volume depletion from empagliflozin; caution in patients on diuretics or with low blood pressure.
3. Ketoacidosis:
•    May occur even with normal blood glucose levels. Seek medical help immediately for symptoms like nausea, vomiting, fatigue, or difficulty breathing.
________________________________________
Pregnancy Category
•    Consult your physician before use.
________________________________________
Storage
•    Store at room temperature, away from moisture, direct light, and heat.