Elzanor Tablets 5mg/1000mg

Medicine Name: Elzanor Tablets 5/1000mg

Elzanor 5 mg / 1000 mg Tablets
Requires Prescription:
Yes
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Generics:
Empagliflozin 5 mg + Metformin Hydrochloride 1000 mg
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Used For:
Type 2 Diabetes Mellitus
•    As an adjunct to diet and exercise
•    For patients not adequately controlled with metformin alone or already using both empagliflozin and metformin
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How It Works:
•    Empagliflozin is a SGLT2 inhibitor that lowers blood glucose by preventing glucose reabsorption in the kidneys, causing excess glucose to be excreted in urine.
•    Metformin is a biguanide that lowers blood glucose by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity.
Together, they target different mechanisms to improve blood sugar control effectively.
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Elzanor Tablets Usage and Safety
Dosage:
•    One tablet once or twice daily, usually with meals to reduce gastrointestinal side effects.
•    Dose may be adjusted by a physician based on response and tolerability.
Side Effects:
Empagliflozin-related (common):
•    Urinary tract infections
•    Increased urination
•    Genital infections (especially in females)
Metformin-related (common):
•    Diarrhea
•    Nausea or vomiting
•    Flatulence
•    Abdominal pain
•    Loss of appetite
•    Metallic taste
•    Headache
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Drug Interactions:
•    Diuretics: May enhance risk of dehydration and hypotension
•    Alcohol: Increases risk of lactic acidosis
•    Cimetidine: May increase metformin levels
•    Insulin or sulfonylureas: May cause hypoglycemia when used together
•    Ranolazine, dolutegravir, vandetanib: May increase metformin exposure
•    NSAIDs and ACE inhibitors: Can impair kidney function and interact with both components
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Indications:
Elzanor 5 mg/1000 mg is indicated to:
•    Improve glycemic control in adults with type 2 diabetes mellitus
•    Be used when diet and exercise alone or monotherapy with either component is insufficient
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When Not to Use:
•    Type 1 diabetes mellitus
•    Diabetic ketoacidosis (DKA)
•    Severe renal impairment or end-stage renal disease (eGFR < 30 mL/min/1.73 m²)
•    History of serious hypersensitivity to empagliflozin, metformin, or any excipients
•    Metabolic acidosis, including lactic acidosis
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Precautions:
•    Monitor renal function before and during treatment
•    Use cautiously in elderly patients, especially if taking diuretics or antihypertensives
•    Assess for symptoms of dehydration, hypotension, or ketoacidosis
•    Avoid excessive alcohol consumption
•    Instruct patients on hydration and genital hygiene
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Warnings:
1. Lactic Acidosis:
•    A rare but potentially fatal complication of metformin, especially in patients with renal impairment, liver disease, or dehydration.
2. Hypotension:
•    Due to volume depletion from empagliflozin; risk increased in elderly or those on diuretics.
3. Ketoacidosis:
•    Can occur even with near-normal blood glucose levels (euglycemic DKA); symptoms include nausea, vomiting, abdominal pain, shortness of breath, and confusion.
4. Genital and Urinary Tract Infections:
•    Higher risk due to glucosuria; counsel on proper hygiene and monitor for signs of infection.
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Pregnancy Category:
Use only if clearly needed. Always consult a healthcare provider before use in pregnancy or breastfeeding.
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Storage:
•    Store at room temperature
•    Keep away from heat, moisture, and direct sunlight
•    Keep out of reach of children