Entamizole Ds Tablets 500mg/400mg

Medicine Name: Entamizole Ds Tablets 500mg/400mg

Entamizole DS Tablets Specification
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Requires Prescription
Yes
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Generics
Diloxanide Furoate
Metronidazole
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Used For
Treatment of Bacterial and Protozoal Infections, specifically:
Acute Amoebiasis
Chronic Amoebiasis
Hepatic Amoebiasis
Giardiasis
Systemic diseases caused by Entamoeba histolytica
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How It Works
Metronidazole acts by disrupting DNA synthesis in anaerobic bacteria and protozoa, leading to cell death.
Diloxanide Furoate is a luminal amoebicide that eradicates amoeba from the intestinal tract by blocking parasite activity and interfering with energy production.
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Usage and Safety
Dosage
Combination of Diloxanide Furoate and Metronidazole
Exact dose and duration to be determined by a healthcare provider based on the condition
Side Effects
Common: Gastrointestinal upset, metallic taste (dysgeusia), dark urine
Occasional: Leucopenia, urticaria, angioedema, central nervous system disturbances
Rare/Serious: Peripheral neuropathy, epileptiform seizures (especially with prolonged use), severe bullous skin reactions
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Drug Interactions
Alcohol (risk of disulfiram-like reaction)
Anticoagulants (e.g., warfarin – may potentiate bleeding)
Phenobarbital and phenytoin (may alter metronidazole levels)
Lithium (risk of lithium toxicity)
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Indications
Treatment of amoebiasis (intestinal and hepatic forms)
Giardiasis
Other protozoal infections caused by E. histolytica
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When Not to Use
Contraindicated in:
Hypersensitivity to metronidazole, diloxanide furoate, or any excipients
Alcohol intoxication or regular alcohol consumption
Liver disease
History of seizures or low seizure threshold
Peripheral neuropathy (e.g., tingling or pain in limbs)
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Precautions
Inform your doctor if you are allergic to metronidazole, tinidazole, or similar antibiotics
Use cautiously in patients with blood, liver, or kidney disorders
Avoid alcohol during and at least 48 hours after the last dose
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Warnings
Warning 1 – Organ Monitoring
Inform your doctor if you have a history of liver, kidney, or hematologic disorders before starting treatment.
Warning 2 – Pregnancy
Use during pregnancy only if clearly necessary and after risk-benefit assessment by a physician.
Warning 3 – CNS Effects
May cause drowsiness, dizziness, or seizure risk. Do not drive or operate heavy machinery unless you are sure of your tolerance.
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Additional Information
Pregnancy Category
Always consult your physician before use.
Storage (YES/NO)
Yes – Store at room temperature, away from direct light and heat.