Estezene Tablets 1mg

Medicine Name: Estezene Tablets 1mg

📋 Estezene Tablets – Specification Sheet
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🔒 Requires Prescription
Yes
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💊 Generics
Trifluoperazine Hydrochloride
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🩺 Used For
•    Schizophrenia (treatment and relapse prevention)
•    Anxiety and depression (short-term, low dose)
•    Nausea and vomiting (supportive use)
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⚙️ How It Works
Trifluoperazine is a piperazine phenothiazine antipsychotic with:
•    Potent antipsychotic, anxiolytic, and antiemetic effects
•    Moderate sedative and hypotensive actions
•    Strong tendency to cause extrapyramidal symptoms (EPS)
It works by blocking dopamine receptors in the brain, balancing neurotransmitters that influence mood, perception, and nausea control.
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📈 Indication
•    High doses: Treatment and prevention of schizophrenia and related psychoses
•    Low doses: Short-term management of anxiety and depression
•    Can also be used for nausea and vomiting relief
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🚫 When Not to Use
•    Allergy to trifluoperazine or related phenothiazines
•    Liver disease, blood disorders, or heart failure
•    Patients in coma or on CNS depressants
•    Severe circulatory collapse
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💡 Precautions
•    Monitor for venous thromboembolism (VTE); assess all potential risk factors before and during treatment
•    Caution in patients with:
o    Epilepsy
o    Parkinson’s disease
o    Prostatic hypertrophy
o    Glaucoma
o    Myasthenia gravis
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⚠️ Warnings
1.    Discontinue immediately at the first signs of tardive dyskinesia or Neuroleptic Malignant Syndrome (NMS)
2.    May worsen Parkinson's symptoms and reverse levodopa effects
3.    Avoid abrupt withdrawal – may cause nausea, vomiting, and insomnia
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❗ Side Effects
Common to Rare
•    Blood-related: Leukopenia, thrombocytopenia, agranulocytosis, blood dyscrasias
•    Neurological: EPS (dystonias, dyskinesias, Parkinsonism), drowsiness, dizziness, agitation, insomnia, seizures, convulsions, mental dullness
•    Cardiac: Tachycardia, hypotension, ECG changes
•    Endocrine/Metabolic: Hyperprolactinemia, anorexia
•    Skin: Rash, erythema, photosensitivity
•    Other: Anticholinergic effects, jaundice, neuroleptic malignant syndrome (rare)
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🔗 Drug Interactions
•    CNS depressants (e.g. codeine, sedatives) – increased sedation
•    Antidepressants, anticonvulsants, Parkinson's meds (levodopa) – reduced efficacy
•    Blood thinners (warfarin) – interaction risk
•    QT-prolonging meds (e.g. amiodarone, quinidine) – increased cardiac risk
•    Diuretics – may cause electrolyte imbalance
•    Desferrioxamine, antacids, neuroleptics, anticholinergics
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💉 Dosage
•    Individualized per patient condition and response
•    Use low dose for anxiety/depression, high dose for schizophrenia
•    Physician-guided titration required
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👶 Pregnancy Category
Consult physician before use
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🧴 Storage
Yes
•    Store at room temperature
•    Keep away from direct sunlight, moisture, and heat