Estezene Tablets 5mg

Medicine Name: Estezene Tablets 5mg

📄 Estezene Tablets – Specification Sheet
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✅ Requires Prescription
Yes
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💊 Generic Name
Trifluoperazine Hydrochloride
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🧠 Used For
•    Schizophrenia (treatment and prevention of relapse)
•    Anxiety and Depression (low-dose, short-term use)
•    Nausea and Vomiting
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⚙️ How It Works
Trifluoperazine is a piperazine phenothiazine tranquilizer with:
•    Potent antipsychotic, anxiolytic, and antiemetic activity
•    Moderate sedative and hypotensive effects
•    A high likelihood of causing extrapyramidal reactions
It acts by blocking dopamine receptors in the brain, restoring neurotransmitter balance.
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💊 Dosage
•    Generic: Trifluoperazine HCl
•    Dosage and duration should be determined by a physician based on the condition and response.
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⚠️ Side Effects
Common to Rare:
•    Blood: Leucopenia, thrombocytopenia, agranulocytosis, blood dyscrasias
•    Hormonal: Hyperprolactinaemia
•    Neurological: Extrapyramidal symptoms (EPS), Parkinsonism, dystonias, dyskinesias, convulsions, dizziness, drowsiness, mental dullness, insomnia, agitation
•    Cardiovascular: Hypotension, tachycardia, ECG changes
•    GI/Metabolic: Anorexia, depression
•    Skin: Rash, erythemas, photosensitivity
•    Rare: Jaundice, neuroleptic malignant syndrome (NMS)
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🔗 Drug Interactions
May interact with:
•    CNS depressants (e.g. codeine, sedatives)
•    Antidepressants (e.g. lithium, phenothiazines)
•    Anticholinergics (e.g. atropine, procyclidine)
•    Anticonvulsants
•    Levodopa (reduces its effect)
•    Anticoagulants (e.g. warfarin)
•    Desferrioxamine, antacids, neuroleptics, diuretics (electrolyte imbalance risk)
•    QT-prolonging agents (e.g. amiodarone, quinidine)
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📌 Indication
•    Low-dose: Management of anxiety and depression for short periods
•    High-dose: Treatment and prevention of schizophrenia
•    Relief of nausea and vomiting
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🚫 When Not to Use
Do not use if:
•    Hypersensitive to trifluoperazine or phenothiazines
•    History of liver disease, blood disorders, or heart failure
•    Patient is in coma, especially with CNS depressant use
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⚠️ Warnings
1.    Discontinue immediately if signs of tardive dyskinesia or neuroleptic malignant syndrome appear.
2.    May exacerbate Parkinson's disease and reverse levodopa effects; caution in epilepsy, glaucoma, myasthenia gravis, and prostatic hypertrophy.
3.    Avoid abrupt withdrawal after high-dose therapy — may cause nausea, vomiting, and insomnia.
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🛡️ Precautions
•    Assess for venous thromboembolism (VTE) risk before and during treatment.
•    Monitor patients with predisposing conditions carefully throughout therapy.
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👶 Pregnancy Category
Always consult your physician before using this medication during pregnancy.
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🧴 Storage
Yes
•    Store at room temperature
•    Keep away from direct light, heat, and moisture