Extor Tablets 5/160mg

Medicine Name: Extor Tablets 5/160mg

🩺 Extor 5/160mg Tablets – Product Specification
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✅ Requires Prescription
Yes
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🧪 Generic Name
Amlodipine Besilate 5mg + Valsartan 160mg
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💊 Used For
•    Treatment of essential hypertension (high blood pressure), particularly in patients whose blood pressure is not adequately controlled by either drug alone.
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⚙️ How It Works
•    Amlodipine (5 mg): A calcium channel blocker (dihydropyridine type) that relaxes blood vessels, lowering peripheral resistance.
•    Valsartan (160 mg): An angiotensin II receptor blocker (ARB) that prevents vasoconstriction and aldosterone release.
These medications work synergistically to reduce blood pressure more effectively together than individually.
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📦 Dosage
•    Form: Oral tablet
•    Strength: Amlodipine 5 mg + Valsartan 160 mg
•    Dosage should be individualized and directed by a physician.
•    Usually taken once daily, with or without food.
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⚠️ Side Effects
Common side effects include:
•    Dizziness, headache, fatigue
•    Swelling (peripheral edema)
•    Nasopharyngitis, sore throat
•    Nausea, abdominal discomfort
•    Hypotension (low blood pressure)
•    Increased potassium levels (hyperkalemia)
•    Flushing, palpitations
•    Muscle or joint pain
Serious (rare) side effects:
•    Angioedema (swelling of lips, tongue, throat)
•    Kidney impairment
•    Liver enzyme abnormalities
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🔄 Drug Interactions
•    Potassium-sparing diuretics, potassium supplements, or salt substitutes
•    NSAIDs (may reduce antihypertensive effect and affect kidneys)
•    Lithium (risk of lithium toxicity)
•    CYP3A4 inhibitors/inducers (affect amlodipine levels)
o    Inhibitors: e.g., ketoconazole, erythromycin
o    Inducers: e.g., rifampin, St. John's Wort
•    Simvastatin (limit dose when combined with amlodipine)
•    Alcohol (may increase risk of hypotension)
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📌 Indication
•    For the management of hypertension in patients who require combination therapy.
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🚫 When Not to Use
•    Hypersensitivity to amlodipine, valsartan, dihydropyridines, or excipients
•    Pregnancy, especially in the 2nd and 3rd trimester
•    Severe hepatic impairment, biliary cirrhosis, or cholestasis
•    History of angioedema related to ARBs or ACE inhibitors
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🛡️ Precautions
•    Monitor renal function, electrolytes, and blood pressure regularly
•    Caution in renal artery stenosis, heart failure, severe renal impairment, or volume depletion
•    Avoid abrupt discontinuation
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⚠️ Warnings
1.    Hyperkalemia Risk
Monitor potassium closely when used with potassium-altering agents.
2.    Risk of Angioedema
Stop treatment if angioedema occurs; do not restart.
3.    Not for Hypertensive Crisis
This formulation is not intended for emergency blood pressure lowering.
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🚼 Pregnancy Category
•    Not recommended during pregnancy; may cause fetal harm.
•    Use effective contraception during treatment.
•    Consult your doctor before use.
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🧴 Storage
Yes
•    Store at room temperature (15–30°C)
•    Keep away from direct light, moisture, and heat