Extor Tablets 5/80mg

Medicine Name: Extor Tablets 5/80mg

🩺 Extor Tablets – Product Specification
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✅ Requires Prescription
Yes
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🧪 Generic Name
Amlodipine Besilate + Valsartan
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💊 Used For
•    Treatment of Hypertension (High Blood Pressure)
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⚙️ How It Works
•    Amlodipine is a calcium channel blocker that relaxes blood vessels by inhibiting calcium entry into vascular smooth muscle.
•    Valsartan is an angiotensin II receptor blocker (ARB) that prevents vasoconstriction and reduces aldosterone secretion.
Together, these two agents have complementary and additive antihypertensive effects, effectively lowering blood pressure more than either drug alone.
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📦 Dosage
•    Form: Oral tablet
•    Active Ingredients: Amlodipine Besilate + Valsartan
•    Dosage is individualized and should be prescribed by a healthcare provider based on the patient's condition.
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⚠️ Side Effects
Common side effects include:
•    Flu-like symptoms: Nasopharyngitis, influenza
•    General: Headache, dizziness, fatigue, asthenia
•    Edema: Facial, peripheral, pitting edema
•    Electrolyte imbalances: Hypokalemia, hyponatremia, hyperuricemia, hypercalcemia
•    Gastrointestinal: Nausea, diarrhea, constipation, dry mouth, abdominal pain
•    Neurological: Vertigo, somnolence, paresthesia, coordination issues
•    Cardiovascular: Palpitations, tachycardia, orthostatic hypotension
•    Dermatologic: Rash, erythema
•    Musculoskeletal: Back pain, joint swelling, arthralgia
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🔄 Drug Interactions
Use with caution or avoid with:
•    Other antihypertensives (additive effects)
•    Grapefruit or grapefruit juice (affects amlodipine metabolism)
•    CYP3A4 inhibitors: E.g., azole antifungals, macrolide antibiotics, verapamil, diltiazem
•    CYP3A4 inducers: E.g., rifampin, St. John’s Wort
•    Lithium (risk of toxicity)
•    Potassium-related products: Supplements, salt substitutes, potassium-sparing diuretics
•    NSAIDs: Risk of renal dysfunction
•    Simvastatin: May increase simvastatin levels
•    Sildenafil: May enhance hypotensive effect
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📌 Indications
•    For the treatment of essential hypertension, particularly in patients who are inadequately controlled on monotherapy.
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🚫 When Not to Use
Avoid use in:
•    Hypersensitivity to amlodipine, valsartan, dihydropyridine derivatives, or excipients
•    Severe hepatic impairment, biliary cirrhosis, or cholestasis
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🛡️ Precautions
•    Use with caution in patients with unilateral/bilateral renal artery stenosis or single kidney, as renal function may deteriorate.
•    Regular monitoring of renal function and serum electrolytes, especially potassium, is recommended.
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⚠️ Warnings
1.    Hyperkalemia Risk
Concomitant use with potassium supplements, salt substitutes, or potassium-sparing drugs requires frequent serum potassium monitoring.
2.    Not for Hypertensive Crisis
Amlodipine’s role in hypertensive emergencies is not established.
3.    Angioedema Alert
Discontinue immediately if angioedema occurs. Do not restart the medication in affected individuals.
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🚼 Pregnancy Category
•    Not recommended during pregnancy, especially second and third trimesters due to risk of fetal toxicity.
•    Always consult your doctor before use.
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🧴 Storage
Yes
•    Store at room temperature, away from direct heat and light