Glucovance Tablets 2.5/500mg

Medicine Name: Glucovance Tablets 2.5/500mg

Glucovance Tablets Specification
Requires Prescription: ✅ Yes
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Generics:
Glibenclamide
Metformin Hydrochloride
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Used For:
Management of Type 2 Diabetes Mellitus
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How It Works:
Metformin Hydrochloride reduces both fasting and postprandial blood glucose by:
Decreasing hepatic glucose production
Reducing intestinal glucose absorption
Enhancing insulin sensitivity
Glibenclamide (a sulfonylurea) lowers blood glucose by:
Stimulating insulin release from pancreatic β-cells
Requires functioning pancreatic cells
Together, they improve glycemic control through complementary mechanisms.
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Dosage:
Contains a fixed-dose combination of Glibenclamide and Metformin HCl
To be used under medical supervision, with individualized dosing
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Side Effects:
Diarrhea
Headache
Nausea / Vomiting
Abdominal pain
Dizziness
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Drug Interactions:
May increase blood glucose:
Thiazide diuretics
Corticosteroids
Phenothiazines
Estrogens, oral contraceptives
Thyroid products
Phenytoin
Nicotinic acid
Calcium channel blockers
Sympathomimetics
Isoniazid
Metformin has minimal protein binding, making it less prone to interaction.
Glibenclamide is highly protein-bound, increasing interaction risk with similar drugs (e.g., salicylates, sulfonamides, chloramphenicol, probenecid).
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Indication:
First-line therapy: In combination with diet and exercise when monotherapy is inadequate
Second-line therapy: When monotherapy with sulfonylurea or Metformin fails
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When Not to Use (Contraindications):
Do not use in patients with:
Renal impairment (Creatinine ≥1.5 mg/dL in males, ≥1.4 mg/dL in females)
Congestive heart failure requiring drug treatment
Hypersensitivity to Metformin or Glibenclamide
Metabolic acidosis (including diabetic ketoacidosis)
Acute conditions such as myocardial infarction, shock, septicemia
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Precaution:
Risk of hypoglycemia: Ensure appropriate dosing and patient education
Monitor renal and liver function regularly
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Warnings:
Warning 1:
Renal or hepatic insufficiency can elevate drug levels and increase hypoglycemia risk.
Warning 2:
Elderly, malnourished, or those with adrenal/pituitary insufficiency or alcohol use are at higher risk for hypoglycemia—may have masked symptoms.
Warning 3:
Not recommended for use in children, as safety and effectiveness are not established.
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Additional Information:
Pregnancy Category:
Consult a physician before use.
Storage Required: ✅ Yes
Store at room temperature, away from light and heat