Gravinate 60Ml Liquid 12.5mg/4ml

Requires Prescription:
No
Generic Name:
 Dimenhydrinate
Used For:
 Relief of nausea, vomiting, and vertigo
How It Works:
Dimenhydrinate is believed to work via central anticholinergic activity and by inhibiting
vestibular stimulation. It may act on the medullary chemoreceptor trigger zone and otolith
system, suppressing signals that cause nausea and motion sickness.
Usage and Safety
Dosage:
 Dimenhydrinate (dose as per physician recommendation)
Side Effects:
 Headache
 Dry mouth
 Drowsiness or somnolence
 Difficulty urinating
 Vertigo
 Myasthenia (muscle weakness)
 Increased intraocular pressure
 Confusion, hallucinations
 Memory and balance issues (especially in elderly)
 Difficulty sleeping or moving
 Involuntary muscle movements
Drug Interactions:
 CNS depressants (e.g., tranquilizers, sedatives)
 Monoamine oxidase inhibitors (MAOIs)
 Anticholinergic agents (e.g., atropine, tricyclic antidepressants)
 CYP2D6 substrates (e.g., metoprolol, venlafaxine)
Indications:
 Prevention and relief of:
o Nausea
o Vomiting
o Vertigo
o Motion sickness
When Not to Use:
 Known hypersensitivity to dimenhydrinate or components (diphenhydramine, 8-
chlorotheophylline)
 Use of MAO inhibitors within the last 14 days
 Patients with:
o Narrow-angle glaucoma
o Chronic lung disease
o Prostatic hypertrophy
o Urinary retention
Precautions:
Use with caution in patients with:
 Myasthenia gravis
 Seizure disorders or epilepsy
 Glaucoma
 Asthma or chronic respiratory conditions (e.g., COPD, bronchitis)
 Hepatic or renal impairment
Warnings:
1. Tolerance may develop with continuous use. Seek medical attention for persistent
symptoms.
2. Avoid using other antihistamines (oral or topical) concurrently.
3. Use with caution in the elderly, due to higher risk of side effects such as confusion and
balance issues.
Pregnancy Category:
 Consult a physician before use during pregnancy or breastfeeding.
Storage:
 Yes, store at room temperature, away from direct light and heat