Muscoril Capsules 4MG

Medicine Name: Muscoril Capsules 4mg
✅Muscoril Capsules Specification
📌 Requires Prescription
Yes
💊 Generic Name
Thiocolchicoside
⚕️ Used For
 Muscle spasms
 Back pain (e.g., low back pain, dorsal pain)
 Torticollis
 Neurological and traumatological disorders
 Degenerative vertebral disorders
 Vertebral static problems
⚙️ How It Works
Thiocolchicoside is a muscle relaxant that selectively binds to GABA-A receptors.
 It activates GABAergic inhibitory pathways, which reduce muscular contractures.
 This results in muscle relaxation, especially in painful spasmodic conditions.
⚕️ Dosage
 As prescribed by a physician
 Usual adult dosage: 8 mg twice daily, or as advised
⚠️ Side Effects
🔹 Common:
 Generally well-tolerated
🔹 Rare:
 Diarrhea
 Gastric pain, heartburn
 Drowsiness
🔹 Very Rare:
 Skin rash, erythema
🔄 Drug Interactions
 Avoid concurrent use with other centrally acting muscle relaxants.
Combination may lead to additive muscle-relaxing effects and increased side effects.
🚫 When Not to Use
Contraindicated in:
 Hypersensitivity to thiocolchicoside or any component
 Pregnancy and lactation
 Women of childbearing potential not using effective contraception
⚖️ Precautions
 If diarrhea occurs, consider reducing the dosage
 Monitor hepatic function during use, especially if combined with NSAIDs or
paracetamol
⚠️ Warnings
⚠️ 1. Genotoxicity Risk
 Preclinical studies show that thiocolchicoside metabolite can cause aneuploidy at
human-equivalent doses.
 Aneuploidy is associated with risks of:
o Teratogenicity
o Spontaneous abortion
o Cancer
o Impaired male fertility
 Avoid long-term use or use at higher-than-recommended doses
⚠️ 2. Liver Toxicity
 Cytolytic and cholestatic hepatitis cases reported, especially with concurrent
NSAIDs/paracetamol
 Patients should immediately stop treatment and report liver-related symptoms
⚠️ 3. Seizure Risk
 May induce seizures, especially in:
o Epileptic patients
o Those at risk for seizures
 Caution advised in these populations
🤰 Pregnancy Category
 Contraindicated in pregnancy
 Always consult a physician before use, especially in women of childbearing potential
⚕️ Storage
Yes
 Store at room temperature
 Keep away from direct light and heat