Nexum Capsules 40MG

Medicine Name: Nexum Capsules 40mg
✅ Nexum Capsules – Product Specification
📌 Requires Prescription:
Yes
💊 Generic Name:
Esomeprazole
⚕️ Used For:
 Acidity
 Heartburn
 Gastroesophageal Reflux Disease (GERD)
 Gastritis
 Peptic Ulcers
⚙️ How It Works:
Esomeprazole is a proton pump inhibitor (PPI) that works by irreversibly binding to the
H⁺/K⁺ ATPase enzyme on the gastric parietal cells.
This enzyme is the final step in gastric acid production, and its inhibition leads to a significant
decrease in stomach acid and an increase in gastric pH, providing relief from acid-related
conditions and promoting healing.
⚕️ Dosage:
 Contains Esomeprazole (strength per formulation as prescribed)
 Administered once daily, preferably before meals
 Dosage should be as per doctor’s prescription
⚠️ Side Effects:
🔸 Common:
 Headache
 Gastrointestinal upset (e.g., nausea, abdominal pain, constipation, diarrhea)
 Dry mouth
 Skin reactions (rash, itching)
🔸 Rare:
 Angioedema
 Anaphylaxis
 Fundic gland polyps
🔄 Drug Interactions:
Use with caution alongside:
 Phenytoin, Warfarin
 Clopidogrel (avoid co-administration)
 Ketoconazole, Itraconazole, Voriconazole
 Diazepam, Citalopram, Imipramine, Clomipramine
 Tacrolimus, Digoxin, Erlotinib, Methotrexate
 CYP3A4 inhibitors or inducers (e.g., Rifampicin, St. John’s Wort)
🚫 When Not to Use:
 Known hypersensitivity to esomeprazole or other PPIs
 Severe allergic reactions such as angioedema, anaphylaxis, bronchospasm, acute
interstitial nephritis, or urticaria previously experienced with PPIs

⚖️ Precautions:
 Long-term use (more than 3 years) may cause vitamin B12 deficiency due to impaired
absorption
 Use with caution in patients at risk of nutrient malabsorption
⚠️ Warnings:
1. Hypomagnesemia may occur with prolonged PPI use; monitor magnesium levels
especially if patient is also on digoxin or diuretics.
2. Increased risk of bone fractures (hip, wrist, spine) with long-term or high-dose PPI
therapy, especially in elderly or osteoporotic patients.
3. Avoid co-administration with Clopidogrel due to reduced antiplatelet activity.
🤰 Pregnancy Category:
Always consult your physician before using during pregnancy or lactation.
⚕️ Storage:
Yes
 Store at room temperature
 Keep away from direct sunlight and heat